Reviewed by Zalman S. Agus, MD; Emeritus Professor
University of Pennsylvania School of Medicine and
Dorothy Caputo, MA, RN, BC-ADM, CDE, Nurse Planner
STOCKHOLM -- Certain genetic patterns carried on the Y chromosome from father to son may hold the key to the "male disadvantage" in heart disease, researchers suggested.
Men carrying the I haplogroup within the male-specific region of the Y chromosome also carried 55% higher age-adjusted coronary artery disease risk (P=0.0002) compared with all others, Nilesh J. Samani, MD, of the University of Leicester, England, and colleagues found in pooled results of two British cohorts.
Y chromosome haplogroup didn't correlate with traditional risk factors in the study, indicating it is an independent predictor not explained by age, LDL or HDL cholesterol, hypertension, or smoking status, the researchers suggested.
"Genetic variation in the Y chromosome is a novel independent risk factor for coronary artery disease," they concluded in a presentation slated for the European Society of Cardiology meeting here next week./.../
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