Exercise and Hypothalamic ER Stress

“Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress

1 Department of Physiology, School of Medicine, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela, Spain, 2 CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Santiago de Compostela, Spain Pablo Blanco Martínez de Morentin^1,2, Miguel López^1,2*

Citation: Martínez de Morentin PB, López M (2010) “Mens Sana In Corpore Sano”: Exercise and Hypothalamic ER Stress. PLoS Biol 8(8): e1000464. doi:10.1371/journal.pbio.1000464

Published: August 24, 2010

Copyright: © 2010 Martínez de Morentin, López. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funding: This work has been supported by grants from Fondo Investigationes Sanitarias (PS09/01880;http://www.isciii.es) and Ministerio de Educacion y Ciencia (RyC-2007-00211; http://www.educacion.es). CIBER de Fisiopatología de la Obesidad y Nutrición (www.ciberobn.es) is an initiative of ISCIII (http://www.isciii.es). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Competing interests: The authors have declared that no competing interests exist.

Abbreviations: ER, endoplasmic reticulum; ERAD, endoplasmic reticulum-associated degradation; IKKβ/NF-ΚB, inhibitor of nuclear factor kappa-B kinase subunit beta/ nuclear transcription factor kappa-B; IL-6: interleukin-6, IL-10, interleukin-10; NPY, neuropeptide Y; POMC, proopiomelanocortin; PTP1B, protein tyrosine phosphatase 1B; SOCS3, suppressor of cytokine signaling 3; STAT3, signal transducer and activator of transcription 3; UPR, unfolded protein response; WAT, white adipose tissue

* E-mail: m.lopez@usc.es