Worldwide burden of disease from exposure to second-hand smoke: data from 192 countries

"Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries"
M Oberg, M Jaakkola, A Woodward, A Peruga, and A Pruss-Ustun
The Lancet 2010; published online 26 November 2010 (open access online)
http://bit.ly/h9N4Iw (ProCOR)

Background
 Exposure to second-hand smoke is common in many countries but the magnitude of the problem worldwide is poorly described. We aimed to estimate the worldwide exposure to second-hand smoke and its burden of disease in children and adult non-smokers in 2004.
Methods
 The burden of disease from second-hand smoke was estimated as deaths and disability-adjusted life-years (DALYs) for children and adult non-smokers. The calculations were based on disease-specifi c relative risk estimates and area-specifi c estimates of the proportion of people exposed to second-hand smoke, by comparative risk assessment methods, with data from 192 countries during 2004.
Findings Worldwide, 40% of children, 33% of male non-smokers, and 35% of female non-smokers were exposed to second-hand smoke in 2004. This exposure was estimated to have caused 379 000 deaths from ischaemic heart disease, 165 000 from lower respiratory infections, 36 900 from asthma, and 21 400 from lung cancer. 603 000 deaths were attributable to second-hand smoke in 2004, which was about 1·0% of worldwide mortality. 47% of deaths from second-hand smoke occurred in women, 28% in children, and 26% in men. DALYs lost because of exposure to secondhand smoke amounted to 10·9 million, which was about 0·7% of total worldwide burden of diseases in DALYs in 2004. 61% of DALYs were in children. The largest disease burdens were from lower respiratory infections in children younger than 5 years (5 939 000), ischaemic heart disease in adults (2 836 000), and asthma in adults (1 246 000) and children (651 000).
Interpretation 
These estimates of worldwide burden of disease attributable to second-hand smoke suggest that substantial health gains could be made by extending eff ective public health and clinical interventions to reduce passive smoking worldwide.