Effects of a Highly Selective Acetylcholine-activated K+ Channel Blocker on Experimental Atrial Fibrillation

Taiichi Machida1,  et al.

Abstract

Background—The acetylcholine-activated K⁺ current (I_K,ACh) is a novel candidate for atrial-specific antiarrhythmic therapy. This study investigates the involvement of I_K,ACh in atrial fibrillation (AF) using NTC-801, a novel potent and selectiveI_K,ACh blocker.

Conclusions—A selective I_K,ACh blockade induced by NTC-801 exerted anti-AF effects mediated by atrial-selective ERP prolongation. These findings suggest thatI_K,ACh may be important in the development and maintenance of atrial fibrillation.