Leicester, Oxford, and Cambridge, UK - An international group of scientists have discovered five new genes that affect the risk of developing coronary artery disease (CAD), which should shed light on new pathways involved in heart disease.
The research, published online on September 22 in PLoS Genetics [1], was led by four British scientists: Professor Nilesh Samani (University of Leicester, UK), Professor Hugh Watkins (University of Oxford, UK), and Professor John Danesh and Dr Adam Butterworth (both from Cambridge University, UK).
Butterworth explained to heartwire that they looked for 50 000 variations in 2000 genes thought to be influential in cardiovascular disease (CVD) in 15 500 patients with heart disease (cases) and 35 000 healthy controls. By comparing the occurrence of each variant between cases and controls, they confirmed the 24 variants already known and identified five new variants that contribute to heart disease risk.
They then validated their results in another 17 000 patients with heart disease and 40 000 healthy controls.
Butterworth said that the most immediate impact of the new gene variants would be the signaling of new pathways involved in heart disease. "They are leading us to investigate new biology that we had not considered before to be involved in heart disease."
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