December 21, 2011 — A molecular signature found in serum samples may predict future development of Alzheimer's disease (AD), even before the first symptoms of the disease occur in patients, new research suggests.
In a cohort study of more than 100 elderly patients with mild cognitive impairment (MCI), investigators found that those who progressed to AD less than 4 years later had a molecular signature suggesting a state of increased hypoxia.
"The study is important, as it identifies molecular changes associated with AD progression years in advance," lead author Matej Orešič, PhD, research professor of systems biology and bioinformatics at the VTT Technical Research Center of Finland in Espoo, told Medscape Medical News/.../
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