Hidden world: molecules inside cells that grab DNA like rock climbers
Structural Maintenance of Chromosome ProteinsOctober 29, 2012
Imaging the molecular machine MukBEF using flourescent tags attached to its component parts. (credit: University of Oxford)
“Each machine functions in much the same way as a rock-climber clinging to a cliff face,” says Mark Leake of Oxford University’s Department of Physics.
“It has one end anchored to a portion of cellular DNA while the other end opens and closes randomly by using chemical energy stored in a ubiquitous bio-molecule called adenosine triphosphate (ATP), the universal molecular fuel for all living cells. …
Using new imaging technology, Oxford Universityresearchers have found how the molecular machines that remodel genetic material inside cells grab onto DNA like a rock climber looking for a handhold./.../
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