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Photomicrograph of nerve cell during an electrical recording (left), fluorescently labeled nerve cell (right) (credit: Sanford-Burnham Medical Research Institute)
The first experimental drug to boost brain synapses lost in Alzheimer’s disease has been developed by researchers at Sanford-Burnham.
The drug, called NitroMemantine, combines two FDA-approved medicines to stop the destructive cascade of changes in the brain that destroys the connections between neurons, leading to memory loss and cognitive decline.
The decade-long study, led by Stuart A. Lipton, M.D., Ph.D., professor and director of the Del E. Webb Center for Neuroscience, Aging, and Stem Cell Research, who is also a practicing clinical neurologist, shows that NitroMemantine can restore synapses (connections between nerve cells) that have been lost during the progression of Alzheimer’s in the brain./.../
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