Ela comenta que o título remete à teoria que ela publicou em 2009 - de que a reciclagem dos virus influenza em co-evolução com a população humana resulta em variação temporal na distribuição de fenotipos imunoinflamatórios na população, o que explica a variação temporal nos niveis e principais causas de mortalidade e a ocorrência de epidemias por diferentes doenças. Afirma que seu trabalho é consultado com bastante regularidade conforme estatísticas do ResearchGate e ela teme que a ideia seja paulatinamente introduzida na " mainstream" sem referência à autoria, como se simplesmente tivesse se cristalizado do nada no pensamento coletivo, ao invés de como realmente foi - fruto de quase de 20 anos de trabalho duro.
Your comment on Flu survivors are an inflammatory club has been approved and
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http://comments.sciencemag.org
Dear Editor
The title given to this editor's choice note called my attention. Still more
after I read the note and found no relation between the note and the title.
It could well be a journalistic translation (much simplified) of an
epidemiologic theory that I advanced 5 years ago in a paper that, according
to ResearchGate stats, has been frequently accessed by colleagues around the
world.
I proposed that the recycling of influenza A viruses in co-evolution with
human populations results in an ever-changing population mixture of
individuals’ immune-inflammatory phenotypes, secularly expressed as changes
in level and distribution of causes of deaths, including epidemics/pandemics
by different diseases (1).
I am afraid that my idea might be finnaly entering the mainstram as one of
those ideas that suddenly "materializes" within the collective thought,
without reference to authorship. The theory is important, even revolutionary
in terms of our understanding of diseases causation. And it is fruit of many
years of hard work(10):
In 1992, when the diet-heart hypothesis and the degenerative paradigm were
the only possible frameworks to any explanation to the rise and fall in CHD
mortality, I finished the first draft of my hypothesis paper, showing a
birth-cohort association between the (young-adult) population with higher
mortality in the 1918 Influenza Pandemic and the (middle-age) population with
highest CHD mortality during the 1950 and 60s. In 1994, I first presented the
association publically, as a poster, in a meeting on Atherosclerosis, and
mine was the only abstract mentioning infection. In 1998 I presented it again
(as a poster), in the first world Meeting on Infection and Atherosclerosis,
and mine was the only abstract mentioning Influenza. In 2003, in the first
meeting on Influenza and Coronary Heart Disease, mine was the only study
dealing with Influenza not just as a trigger to an acute CHD event, but also
as an early-life determinant of vulnerability to triggering upon
re-infection, a much more complex idea of disease causation. In 2009, in a
multi-disciplinary conference on mortality and longevity held in Edinburgh, I
presented an updated version extended to the full theory summarized above.
(1) Azambuja MI 2009. Influenza Recycling and secular trends in mortality and
natality. British Actuarial Journal 15, Supplement, 123-150.
(2) Azambuja MI 2010 Inflammation as the cause of Coronary Heart Disease.
Lancet Inf Dis 10: 143-143.
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