Saturday, November 14, 2015

DNA-copying machinery

First complete pictures of cells’ DNA-copying machinery
November 3, 2015

These cartoons show the old "textbook" view of the replisome, left, and the new view, right, revealed by electron micrograph images in the current study. Prior to this study, scientists believed the two polymerases (green) were located at the bottom (or back end) of the helicase (tan), adding complementary DNA strands to the split DNA to produce copies side by side. The new images reveal that one polymerase is located at the front end of the helicase. The scientists are conducting additional studies to explore the biological significance of this unexpected location. (credit: Brookhaven National Laboratory) 
Electron microscope images reveal that structure of DNA-copying protein complex differs from long-held textbook view
The first-ever electron microscope images of the protein complex that unwinds, splits, and copies double-stranded DNA reveal something rather different from the standard textbook view. The images, created by scientists at the U.S. Department of Energy’s Brookhaven National Laboratory with partners from Stony Brook University and Rockefeller University, offer new insight into how this molecular … more…
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