FT4 ; Cancer

Higher FT4 Levels Linked With Cancer Risk

Strongest Links were for lung and breast cancer

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• by Jeff Minerd 
  Contributing Writer, MedPage Today

  September 29, 2016
• This article is a collaboration between MedPage Today® and:
   

Higher thyroid hormone levels were associated with increased cancer risk, according to a prospective cohort study conducted in The Netherlands.

Each unit increase of free thyroxine (FT4) was associated with a 42% increase in risk for any solid cancer (hazard ratio 1.42; 95% CI 1.12-1.79; P<0 .05="" 1.10-2.84="" 1.39-3.2="" 1.77="" 2.33="" 95="" also="" and="" breast="" cancer="" ci="" em="" for="" ft4="" higher="" increased="" linked="" lung="" nbsp="" risk="" style="border: 0px; box-sizing: border-box; font-family: inherit; font-size: inherit; font-stretch: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; vertical-align: baseline;" to="" was="">P

<0 .05="" a="" both="" for="" href="https://www.researchgate.net/profile/Layal_Chaker" nbsp="" reported="" style="border: 0px; box-sizing: border-box; color: #0484d9; font-family: inherit; font-size: inherit; font-stretch: inherit; font-style: inherit; font-variant: inherit; font-weight: inherit; line-height: inherit; margin: 0px; padding: 0px; text-decoration: none; vertical-align: baseline;" target="_blank">Layal Chaker, MD, of Erasmus University in Rotterdam, and colleagues.

Compared with individuals in the lowest FT4 level tertile, those in the highest had a 1.3-fold increased risk for any solid cancer (95% CI 0.99-1.28; P=0.004), a 1.79-fold increased risk for lung cancer (95% CI 1.23-2.59; P=0.002), and a 1.14-fold increased risk for breast cancer (95% CI 0.82-1.58; P=0.019), Chaker and colleagues reported in the Journal of Clinical Endocrinology and Metabolism./.../

Primary Source

The Journal of Clinical Endocrinology and Metabolism

Source Reference: Khan SR, et al "Thyroid function and cancer risk: the Rotterdam study" J Clin Endorinol Metab 2016; DOI: 10.1210/jc.2016-2104