human blood dendritic cells

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RESEARCH ARTICLE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

1. Alexandra-Chloé Villani1,2,*,†, 
2. Rahul Satija1,3,4,*, 
3. Gary Reynolds5, 
4. Siranush Sarkizova1, 
5. Karthik Shekhar1, 
6. James Fletcher5, 
7. Morgane Griesbeck6, 
8. Andrew Butler3,4, 
9. Shiwei Zheng3,4, 
10. Suzan Lazo7, 
11. Laura Jardine5, 
12. David Dixon5, 
13. Emily Stephenson5, 
14. Emil Nilsson8, 
15. Ida Grundberg8, 
16. David McDonald5, 
17. Andrew Filby5, 
18. Weibo Li1,2, 
19. Philip L. De Jager1,9, 
20. Orit Rozenblatt-Rosen1, 
21. Andrew A. Lane1,7, 
22. Muzlifah Haniffa5,10,†, 
23. Aviv Regev1,11,12,†, 
24. Nir Hacohen1,2,†

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Science  21 Apr 2017:
Vol. 356, Issue 6335, eaah4573
DOI: 10.1126/science.aah4573

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What's in a drop of blood?

Blood contains many types of cells, including many immune system components. Immune cells used to be characterized by marker-based assays, but now classification relies on the genes that cells express. Villani et al. used deep sequencing at the single-cell level and unbiased clustering to define six dendritic cell and four monocyte populations. This refined analysis has identified, among others, a previously unknown dendritic cell population that potently activates T cells. Further cell culture revealed possible differentiation progenitors within the different cell populations.

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