A recent multi-centre study, led by King’s College London and the University of Manchester, has established that synapse loss in Alzheimer’s disease is driven by a specific signalling pathway. This pathway is called the Wnt-planar cell polarity (PCP) signalling pathway and it may be pivotal to the progressive neurodegeneration seen in the disease.
The research is in Alzheimer’s & Dementia. (full open access)
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