Aluminium

Aluminum Should Now Be Considered a Primary Etiological Factor in Alzheimer’s Disease

Article type: Editorial

Authors: Exley, Christopher*

Affiliations: The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK

Correspondence: [*] Correspondence to: Christopher Exley, The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, ST5 5BG, UK. E-mail: c.exley@keele.ac.uk.

Keywords: Aluminum, Alzheimer’s disease, brain aluminum, environmental factors, genetic predisposition, human health

DOI: 10.3233/ADR-170010

Journal: Journal of Alzheimer's Disease Reports, vol. 1, no. 1, pp. 23-25, 2017

Accepted 15 May 2017

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Published: 8 June 2017

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Abstract

In this paper, I have summarized the experimental and largely clinical evidence that implicates aluminum as a primary etiological factor in Alzheimer’s disease. The unequivocal neurotoxicity of aluminum must mean that when brain burdens of aluminum exceed toxic thresholds that it is inevitable that aluminum contributes toward disease. Aluminum acts as a catalyst for an earlier onset of Alzheimer’s disease in individuals with or without concomitant predispositions, genetic or otherwise. Alzheimer’s disease is not an inevitable consequence of aging in the absence of a brain burden of aluminum.