Ainda não li tudo, mas o primeiro questionamento que me surgiu foi: quanto de pré-seleção nas amostras, separando gente estressada ou não, cofator para hiperacidez, gastrite e úlcera e motivo para usar antiácido? Estou curioso para saber se isso foi analisado...
2017 Top Stories in Primary Care: Proton Pump Inhibitors and Risk of Death
- Written by
David Rakel MD, FAAFP
Nature intended us to have acid in the stomach for a reason. It helps us absorb nutrients including B vitamins, magnesium, calcium, and iron. There is also a proton pump on each lysosome, allowing these chimney sweeps of the endothelium to function. Inhibiting the proton pump leads to oxidative stress, telomere shortening, and endothelial cell dysfunction.
My choice for top story1 was not the first study to suggest significant risk with long-term proton pump inhibitor (PPI) use. In 2015, a “big-data” study of electronic medical records evaluated a trillion bits of information and showed a twofold increased risk of cardiovascular mortality associated with PPI use, but not with H2 blockers.2
Then, 2 years later in 2017, this paper was published that looked at 1,762,908 US veterans taking PPIs or H2 blockers.1 The primary endpoint was death. The hazard ratio for the risk of death for PPIs vs H2 blockers was 1.25 and for PPI use vs no acid suppressive therapy was 1.23. There was also a graded association with length of PPI use. The longer a veteran was on a PPI, the higher the risk of death./.../
No comments:
Post a Comment