Researchers Successfully Reverse Alzheimer’s Disease: Mouse Studyby Neuroscience News |
Depleting BACE1 completely reverses the formation of amyloid plaques and improves cognitive function in mouse models of Alzheimer's disease, researchers report.
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The brain of a 10-month-old mouse with Alzheimer’s disease (left) is full of amyloid plaques (red) surrounded by activated microglial cells (green). But these hallmarks of Alzheimer’s disease are reversed in animals that have gradually lost the BACE1 enzyme (right). NeuroscienceNews.com image is credited to Hu et al., 2018.
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