anticholinergics and dementia

Recomendado pela AMICOR Berenice Goelzer

Penso que este artigo tenha interesse para Saúde Ocupacional, particularmente para os médicos do trabalho.  

Olhem o link:  http://neurosciencenews.com/dementia-anticholinergics-8884/

 Quando li, lembrei-me que os organophosforados inibem a acetilcolinesterase, levando a acúmulo de acetilcolina.

 ... imagino que pacientes como essas intoxicações sejam eventualmente tratados com medicamentos “anticolinérgicos”, portanto este estudo de side effect deve interessar.

Common Class of Drugs Linked to Dementia, Even When Taken 20 Years Before Diagnosis

NEUROSCIENCE NEWSAPRIL 26, 2018

Summary: Researcherhave identified a link between anticholinergic medications, including antidepressants and incontinence drugs, and an increased risk of developing dementia later in life.

Source: Regenstrief Institute.

The largest and most detailed study of the long-term impact of anticholinergic drugs, a class of drugs commonly prescribed in the United States and United Kingdom as antidepressants and incontinence medications, has found that their use is associated with increased risk of dementia, even when taken 20 years before diagnosis of cognitive impairment.

An international research team from the US, UK and Ireland analyzed more than 27 million prescriptions as recorded in the medical records of 40,770 patients over age 65 diagnosed with dementia compared to the records of 283,933 older adults without dementia./.../