A new study published in JEM reveals blocking a specific receptor on astrocytes improved memory performance and normalized brain function in mouse models of Alzheimer's disease.
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Under the microscope: Star-shaped astrocytes (green) have gathered around pathological protein deposits (purple). These “plaques” are a hallmark of Alzheimer’s disease. NeuroscienceNews.com image is credited to DZNE / Nicole Reichenbach.
New approaches for research and therapies?
Petzold summarizes: “This is an experimental study that is currently not directly applicable to human patients. However, our results suggest that astrocytes, as important safeguards of neuronal health and normal network function, may hold the potential for novel treatment options in Alzheimer’s disease.” In future studies, the scientists intend to identify additional novel pathways in astrocytes and other cells as potential drug targets./.../
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