CRISPR

CRISPR cuts can delete DNA CRISPR-Cas9 gene editing can cause unwanted DNA changes near target sites on the genome. The problem arises because cells are not perfect at repairing the cuts that CRISPR makes in their DNA. Sometimes, segments of DNA will be deleted or rearranged, or unrelated bits of DNA might become incorporated into the chromosome. Such alterations can muddle the interpretation of experimental results and could complicate efforts to design therapies based on CRISPR. Nature | 4 min read Reference: Nature Biotechnology paper