Inflammation

Inflammatory Hypothesis Reaches Dilated Cardiomyopathy

Case report shows 'unprecedented clinical improvement' with an IL-1 blocker

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• by Nicole Lou, Contributing Writer, MedPage TodayJuly 30, 2018

Interleukin-1 suppression helped reverse symptoms of dilated cardiomyopathy (DCM) for one patient in a case study that may implicate inflammation in the development of the condition.

The 57-year-old man with a 2-year history of DCM had been hospitalized for chronic fatigue and dyspnea secondary to heart failure (New York Heart Association class III). Transthoracic echocardiography (TTE) showed a severely dilated left ventricle; left ventricular ejection fraction (LVEF) was 28%. Cardiac catheterization showed normal coronary arteries./.../