Dementia and Hypertension control

Effect of Intensive vs Standard Blood Pressure Control on Probable DementiaA Randomized Clinical Trial

The SPRINT MIND Investigators for the SPRINT Research Group

Article Information

JAMA. 2019;321(6):553-561. doi:10.1001/jama.2018.21442

Question  Does intensive blood pressure control reduce the occurrence of dementia?

Findings  In this randomized clinical trial that included 9361 adults with hypertension, randomization to a systolic blood pressure target of less than 120 mm Hg compared with less than 140 mm Hg resulted in a rate of probable dementia of 7.2 vs 8.6 cases per 1000 person-years, a difference that was not statistically significant.

Meaning  Among adults with hypertension, intensive blood pressure control did not significantly reduce the risk of probable dementia.