Sunscreen substances absortion

May 6, 2019

Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active IngredientsA Randomized Clinical Trial

Murali K. Matta, PhD¹; Robbert Zusterzeel, MD, PhD, MPH¹; Nageswara R. Pilli, PhD¹; et alVikram Patel, PhD¹; Donna A. Volpe, PhD¹; Jeffry Florian, PhD¹; Luke Oh, PhD²; Edward Bashaw, PharmD²; Issam Zineh, PharmD, MPH²; Carlos Sanabria, MD³; Sarah Kemp, RN³; Anthony Godfrey, PharmD³; Steven Adah, PhD⁴; Sergio Coelho, PhD⁴; Jian Wang, PhD⁵; Lesley-Anne Furlong, MD⁵; Charles Ganley, MD⁵; Theresa Michele, MD⁴; David G. Strauss, MD, PhD¹

Author Affiliations Article Information

JAMA. 2019;321(21):2082-2091. doi:10.1001/jama.2019.5586

Question  What is the maximum plasma concentration of active ingredients of various types of sunscreen formulations under maximal use conditions?

Findings  In this randomized clinical trial that included 24 healthy participants and application of 4 commercially available sunscreen formulations, maximum plasma concentrations (geometric mean [coefficient of variation]) for the active ingredient avobenzone were 4.0 (60.9%), 3.4 (77.3%), 4.3 (46.1%), and 1.8 (32.1%) ng/mL for 2 different sprays, a lotion, and a cream, respectively.

Meaning  The systemic absorption of sunscreen active ingredients supports the need for further studies to determine the clinical significance of these findings./.../