Risk of Colon but Not Rectal Cancer Tied to Past Antibiotic Use
Differences in microbiota along the bowel may explain dichotomy
Oral antibiotic use was associated with a small increase in risk of colon cancer but not rectal cancer in a large case-control study of British patients.
The findings -- from nearly 30,000 cancer patients and 137,000 controls -- further underscore the need for judicious use of antibiotics, Cynthia L. Sears, MD, of John Hopkins School of Medicine in Baltimore, and colleagues wrote online in Gut.
Participants who developed colon cancers were slightly but significantly more likely to have used antibiotics than controls: 71.3% vs 69.1% (P<0 .001="" found.="" p="" researchers="" the="">
Those with rectal cancers, on the other hand, had comparable exposure to antibiotics: 67.1% vs 67.2% (P=0.96).
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