New human-mouse chimera is the most human yet
This mouse-human chimera shows human cells (green) in a 17-day-old mouse embryo (blue) that are mostly red blood cells accumulated in the mouse's liver.
(Image: © Zhixing Hu)
A newly-created mouse-human embryo contains up to 4% human cells — the most human cells yet of any chimera, or an organism made of two different sets of DNA.
Surprisingly, those human cells could learn from the mouse cells and develop faster — at the pace of a mouse embryo rather than a more slowly developing human embryo. That finding was "very serendipitous… We did not really foresee that," said senior author Jian Feng, a professor in the department of physiology and biophysics at the State University of New York at Buffalo. /.../
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