3.171 - AMICOR (26)

 3.171 - AMICOR (26) 

#Com Dra. Valderês A. Robinson Achutti (*13/06/1931 +15/06/2021)

No século passado, nas Montanhas Rochosas, no Canadá.

#Re-Publicando apresentações minhas antigas
Tabagismo e Gravidez

Congresso Brasileiro de Cardiologia de 2008 - Curitiba Link

#History Channel

THIS DAY IN HISTORY   January 11

1964 U.S. Surgeon General announces definitive link between smoking and cancer United States Surgeon General Luther Terry knew his report was a bombshell. He intentionally chose to release it on January 11, 1964, a Saturday, so as to limit its immediate effects on the stock market. It was on this date that, on behalf of the U.S. Government, Terry announced a definitive link be... read more

#Med Page Today

Opening Blood-Brain Barrier to Deliver Alzheimer's Drug Shows Promise — Focused ultrasound helped aducanumab reduce amyloid-beta levels by Judy George, Deputy Managing Editor, MedPage Today January 3, 2024

Last Updated January 4, 2024

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Aducanumab (Aduhelm) infusions combined with focused ultrasound led to lower cerebral amyloid-beta levels in Alzheimer's disease, a proof-of-concept trial showed.

The investigational treatment involved creating an opening in the blood-brain barrier with MRI-guided focused ultrasound to boost drug delivery./.../

#World Heart Federation

WHF Observatory

# Arquivos Br. de Cardiologia

Paulo Sérgio Veiga Jardim and  Thiago Jardim 2017, 108 (53-59)

Multiprofessional Treatment of High Blood Pressure in Very Elderly Patients View PDF ▸   Download PDF ⬇

#IHME

Antimicrobial resistance major threat in Africa    Over 1 million people died in the WHO African region in 2019 due to bacterial antimicrobial resistance (AMR) in 2019, according to a new study from The Lancet. The burden of AMR mortality is higher in low-income settings, revealing stark health care inequalities across the region.  AMR deaths have surpassed HIV/AIDS and malaria tolls, emphasizing a critical public health shift as well as a shift in health care priorities. Lower respiratory and thorax infections are a leading cause of death in the WHO African region, and AMR accounts for 48% of these deaths.  The study identified four major pathogens responsible for 100,000 deaths each: Streptococcus pneumoniae Klebsiella pneumoniae Escherichia coli Staphylococcus aureus Read the research Researchers Authia Gray and Dr. Yewande Alimi share insights from this AMR study on a recent episode of the Global Health Insights podcast.   Watch the episode Top Stories Cancer rates rising in Asian countries   New GBD data shows rising cancer rates in Asia, with 9.4 million new cases and 5.6 million deaths in 2019, led by India, China, and Japan. Driven by risk factors including alcohol, smoking, and particulate matter pollution, this escalating health threat requires urgent action. Read the research→ Mysterious kidney failure among farmers   Young and otherwise healthy agricultural workers are developing kidney failure in global hot zones, reports Think Global Health. “There’s something substantial going on,” says Theo Vos, a researcher at IHME. Read the story→ IHME in the News India registered 9.3 lakh cancer deaths, second highest in Asia: Lancet Study (Times of India) » India registered about 12 lakh new cancer cases and 9.3 lakh deaths in 2019, becoming the second largest contributor to the disease burden in Asia for that year, according to a new study published in The Lancet Regional Health Southeast Asia journal. Long COVID is a double curse in low-income nations — here’s why (Nature) » “The main story about long COVID in low- and middle-income countries is that there are relatively few studies,” says Theo Vos, an epidemiologist at the Institute for Health Metrics and Evaluation in Seattle, Washington. “But wherever people have looked at it, they find it.” LinkedIn post of the week  Salvando a los niños 🚸 de las infecciones resistentes a los antibióticos 💊  El aumento del uso de antibióticos está causando que encontremos más bacterias que son resistentes a estos antibióticos!!! Dada la carga que suponen los diferentes países, los síndromes infecciosos y las combinaciones de patógenos y medicamentos, la resistencia a los antimicrobianos representa una amenaza sustancial para la salud en las Américas. — Catia Cilloniz Senior Researcher at Hospital clinic of Barcelona Associate Professor at Universitat of Barcelona/CIBERES What We’re Reading Latin America’s health systems are falling behind the rest of the world, WHO warns » The pandemic, persistent inequality, outdated technology and the consequences of climate change have put progress into reverse. (The Telegraph) As maternal care in Wyoming dwindles, tribal clinics are building up resources for support » Obstetric services have shrunk elsewhere in Wyoming's Fremont County. Tribal patients have greater options. (The 19th News)   Featured Datasets Development Assistance for Health on COVID-19 Database 2020-2022   WHO Africa Region Bacterial Antimicrobial Resistance Burden Estimates 2019

#Quanta Magazine

AGING | ALL TOPICS   Cells Across the Body Talk to Each Other About Aging By VIVIANE CALLIER Biologists discovered that mitochondria in different tissues talk to each other to repair injured cells. When their signal fails, the biological clock starts winding down. Read the blog INFORMATION THEORY   ‘Magical’ Error Correction Scheme Proved Inefficient By BEN BRUBAKER Locally correctable codes need barely any information to fix errors, but they’re extremely long. Now we know that the simplest versions can’t get any shorter. Read the article Related:  Researchers Defeat Randomness to Create Ideal Code By Mordechai Rorvig (2021) MATERIALS SCIENCE   New Kind of Magnetism Spotted in an Engineered Material By MICHAEL GRESHKO In an atomically thin stack of semiconductors, a mechanism unseen in any natural substance causes electrons’ spins to align. Read the blog Related:  Meet Strange Metals: Where Electricity May Flow Without Electrons By Charlie Wood (2023) Q&A   The Theorist Who Sees Math in Art, Music and Writing Interview by LEILA SLOMAN; Video by CHRISTOPHER WEBB YOUNG & EMILY BUDER The links between math and art have been explored for millennia. Sarah Hart is now turning a mathematical eye to literature. Read the interview Watch the video QUANTA SCIENCE PODCAST   Even Synthetic Life Forms With a Tiny Genome Can Evolve By YASEMIN SAPLAKOGLU; Podcast hosted by SUSAN VALOT By watching “minimal” cells regain the fitness they lost, researchers are testing whether a genome can be too simple to evolve. Listen to the podcast Read the article

 

COMPUTER SCIENCE

‘Magical’ Error Correction Scheme Proved Inherently Inefficient

By BEN BRUBAKER
Locally correctable codes need barely any information to fix errors, but they’re extremely long. Now we know that the simplest versions can’t get any shorter.

Read article

#

Top 10 Most Read Pieces from 2023

#MEDSCAPE

Poor Oral Health Tied to Worse Brain Health

Megan Brooks

DISCLOSURES | January 09, 2024

Proper care of teeth and gums may offer benefits beyond oral health, including improving brain health, new research suggests.

In a large observational study of middle-aged adults without stroke or dementia, poor oral health was strongly associated with multiple neuroimaging markers of white matter injury.

"Because the neuroimaging markers evaluated in this study precede and are established risk factors of stroke and dementia, our results suggest that oral health, an easily modifiable process, may be a promising target for very early interventions focused on improving brain health," wrote the authors, led by Cyprien Rivier, MD, MS, with the Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.

The study was published online on December 20, 2023, in Neurology.

#Nature aging

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles

• Betty M. Tijms, 
• Ellen M. Vromen, 
• Olav Mjaavatten, 
• Henne Holstege, 
• Lianne M. Reus, 
• Sven van der Lee, 
• Kirsten E. J. Wesenhagen, 
• Luigi Lorenzini, 
• Lisa Vermunt, 
• Vikram Venkatraghavan, 
• Niccoló Tesi, 
• Jori Tomassen, 
• Anouk den Braber, 
• Julie Goossens, 
• Eugeen Vanmechelen, 
• Frederik Barkhof, 
• Yolande A. L. Pijnenburg, 
• Wiesje M. van der Flier, 
• Charlotte E. Teunissen, 
• Frode S. Berven & 
• Pieter Jelle Visser 

Nature Aging (2024)details

Abstract

Alzheimer’s disease (AD) is heterogenous at the molecular level. Understanding this heterogeneity is critical for AD drug development. Here we define AD molecular subtypes using mass spectrometry proteomics in cerebrospinal fluid, based on 1,058 proteins, with different levels in individuals with AD (n = 419) compared to controls (n = 187). These AD subtypes had alterations in protein levels that were associated with distinct molecular processes: subtype 1 was characterized by proteins related to neuronal hyperplasticity; subtype 2 by innate immune activation; subtype 3 by RNA dysregulation; subtype 4 by choroid plexus dysfunction; and subtype 5 by blood–brain barrier impairment. Each subtype was related to specific AD genetic risk variants, for example, subtype 1 was enriched with TREM2 R47H. Subtypes also differed in clinical outcomes, survival times and anatomical patterns of brain atrophy. These results indicate molecular heterogeneity in AD and highlight the need for personalized medicine.

#World Congress of Cardiology

World Congress of Cardiology: Showcase your science!   Submit your abstracts by 29 February for the chance to share your research on a global stage at the 18th Oriental Congress of Cardiology together with the World Congress of Cardiology.   Don't miss this opportunity to share your insights, engage with experts, and be a part of shaping the future of cardiology around the world!

SUBMIT YOUR ABSTRACTS

#AMRIGS

# Popular Mechanics

The 10 Science Moments You Need to Care About in 2024 If you need a bit of hope for the new year, these imminent breakthroughs should do the trick. Read More