Saturday, June 11, 2016

Genoma building

Scientists plan to build human genome from scratch

June 6, 2016
Efficiency trends in DNA sequencing (green) and synthesis of double-stranded DNA (dsDNA, blue) and single-stranded DNA (ssDNA, red) over the past ~35 years. Double-stranded DNA, or<br /> gene synthesis, has improved noticeably over the past ~10 years, but still lags behind<br /> sequencing and ssDNA synthesis. The disruptive improvement in sequencing and ssDNA (oligonucleotides) synthesis technologies has improved from multiplex and miniaturization technologies in high-throughput DNA sequencing and oligo microarray technologies, respectively. Commercial gene synthesis technologies relies on both oligo synthesis (building blocks) and sequencing (validation of synthesis) technologies. (credit: Jef D. Boeke/Science)
Leading genomics experts have announced Genome Project-write (HGP-write), which aims to synthesize entire genomes of humans and other species from chemical components and get them to function in living cells.
As explained in Science, the goal of HGP-write is to reduce the costs of engineering large genomes, including a human genome, and to develop an ethical framework for genome-scale engineering and transformative medical applications.
Impacts… read more
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