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Wednesday, May 24, 2017

Alzheimer's Treatment

A New Approach to Alzheimer's Treatment

The disease's complexity and multiple contributing factors suggest that combinations of drugs could be more effective than single medications
  • By James Hendrix on May 23, 2017
    • Credit: Gerd Altmann Pixabay
      Having witnessed the success of combination therapy in HIV, cancer and heart disease, the time has come for Alzheimer’s disease. At meetings convened by the Alzheimer’s Association and others, a consensus is emerging that the most effective Alzheimer’s treatments may be those that attack the disease on multiple fronts.

52 genes ~ inteligência

Pesquisa liga 52 genes à inteligência –e os mais espertos fumam menos


Tuesday, May 23, 2017

Oral Anticoagulation : Atrial Fibrillation & Percutaneous Coronary Intervention

Journal Club: Clinical Updates in Oral Anticoagulation for Patients With Atrial Fibrillation Requiring Percutaneous Coronary Intervention

Evaluating Treatment Strategies With a Non–Vitamin K Oral Anticoagulant in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention

Part 1 of 2 from "Journal Club: Clinical Updates in Oral Anticoagulation for Patients With Atrial Fibrillation Requiring Percutaneous Coronary Intervention"
Based on a review of "Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI" (The New England Journal of Medicine. 2016;375:2423-2434).
Content developed in concert with the faculty.
Release Date: 30 January 2017
Expiration Date: 29 July 2018
Learning Objectives
  • Review guidelines and data on the use of oral anticoagulation in patients with atrial fibrillation (AF) requiring percutaneous coronary intervention (PCI)
  • Summarise recently published data from a study evaluating a non–vitamin K oral anticoagulant (NOAC) for the treatment of patients with AF requiring PCI
  • Discuss how these data will impact clinical practice

New Prescription Drugs

Recomendado pela AMICOR Maria Inês Reinert Azambuja

New Prescription Drugs: A Major Health Risk With Few Offsetting Advantages

Few people know that new prescription drugs have a 1 in 5 chance of causing serious reactions after they have been approved. That is why expert physicians recommend not taking new drugs for at least five years unless patients have first tried better-established options, and have the need to do so.
Few know that systematic reviews of hospital charts found that even properly prescribed drugs (aside from misprescribing, overdosing, or self-prescribing) cause about 1.9 million hospitalizations a year. Another 840,000 hospitalized patients are given drugs that cause serious adverse reactions for a total of 2.74 million serious adverse drug reactions. About 128,000 people die from drugs prescribed to them. This makes prescription drugs a major health risk, ranking 4th with stroke as a leading cause of death. The European Commission estimates that adverse reactions from prescription drugs cause 200,000 deaths; so together, about 328,000 patients in the U.S. and Europe die from prescription drugs each year. The FDA does not acknowledge these facts and instead gathers a small fraction of the cases.

Monday, May 22, 2017

Mais rápido que a luz?...

 
22 May 2017

Weird energy beam seems to travel five times the speed of light


Astrophile is Joshua Sokol's monthly column on curious cosmic objects, from the solar system to the far reaches of the multiverse
O jato de M87 é mais do que apenas uma curiosidade.
Em todo o universo, raios de energia disparados de buracos negros maciços podem parar ou iniciar a formação de estrelas. Mas não está claro como esses raios funcionam e quanta energia eles contêm.
Parecendo mover-se mais rapidamente do que a luz, eles mudam visivelmente em apenas alguns anos, o que é incomum para objetos distantes. Isso permite que os astrônomos façam estimativas precisas de quão rápido o plasma está se movendo e, portanto, quão poderoso é esse processo.
A galáxia M87 é especial porque está relativamente próxima de nós em comparação com outras galáxias, tornando-a mais fácil de estudar. Este último estudo, por exemplo, reuniu dados de mais de 20 anos de observação da M87. [NewScientist]/.../

Saturday, May 20, 2017

2816 - AMICOR 20

People in order: age

Aloyzio AchuttiemAMICOR - Há um dia
People in order: age 3 minutes https://aeon.co/videos/ageing-to-the-beat-of-their-own-drums-from-one-to-100-years-old

Sania Nishtar: WHO

Aloyzio AchuttiemAMICOR - Há um dia
Sania Nishtar is the health leader that the world needs George AlleyneEmail the author George Alleyne , Cary Cooper , Pekka Puska , Robert Beaglehole , Ruth Bonita , Alexandre Kalache , Mohamed Abdi Jama , Fareed Minhas , Samad Shera Published: 18 May 2017 [image: Article has an altmetric score of 10] DOI: http://dx.doi.org/10.1016/S0140-6736(17)31356-9Summary - Full Text - References - Supplementary Material Dr Sania Nishtar is the ideal person to lead WHO and we urge the world's 194 health ministers to elect her as the next Director–General (DG) in the coming World He... mais »

World Health Statistics 2017

Aloyzio AchuttiemAMICOR - Há 3 dias
World Health Statistics 2017: Monitoring health for the SDGs The World Health Statistics series is WHO’s annual compilation of health statistics for its 194 Member States. World Health Statistics 2017 compiles data on 21 health-related Sustainable Development Goals (SDG) targets, with 35 indicators, as well as data on life expectancy. This edition also includes, for the first time, success stories from several countries that are making progress towards the health-related SDG targets. - Read the report - Read the news release - Browse the SDG data visualizations dashboard ... mais »

Older physicians

Aloyzio AchuttiemAMICOR - Há 3 dias
News & Perspective Mortality Higher Among Inpatients Treated by Older Physicians Diana Swift May 16, 2017 The sample comprised 736,537 admissions to US acute-care hospitals managed by 18,854 hospitalists. The median age of physicians was 41 years, with 10,177 physicians younger than 40 years, 8016 aged from 40 to 49 years, 3331 aged from 50 to 59 years, and 1086 aged 60 years and older. The characteristics of the patients were comparable across physician age groups, with a mean age of approximately 80.5 years, 60% women, and approximately 83% white. Overall 30-day mortality rate was 11... mais »

Cardiologist Compensation Report 2017

Aloyzio AchuttiemAMICOR - Há 3 dias
Medscape Cardiologist Compensation Report 2017 Cardiologists who responded to this year's Medscape compensation survey disclosed not only their compensation but also how many hours they work per week, how many minutes they spend with each patient, what is most rewarding—and most challenging—about their jobs, and more. (Note: Values in charts have been rounded and may differ from the sums cited in the captions.)

2815 - AMICOR 20

Aloyzio AchuttiemAMICOR - Há 3 dias
AMICOR 20 ANOS - 17/05/1997 - 2017 É uma satisfação conseguir chegar aqui durante todos esses anos, graças à colaboração dos AMICOR, ao incentivo dos amigos conhecidos e dos visitantes que não conheço pessoalmente, mas sabendo que se existem interessados é porque tem gente que aproveita e aprecia o trabalho de busca da informação e seleção. Como já ficou expresso na introdução dessa atividade sobre seu propósito de colocar a disposição de amigos e visitantes aquilo que para mim me parece interessante, para examinar no ato ou para guardar para ver com detalhe mais adiante, inclusive... mais »

João Carlos Cechella 25 anos de transplante cardíaco. Viva!

Aloyzio AchuttiemAMICOR - Há 3 dias
*Homenagem para meu primo e para a equipe que o tem assistido, com votos de saúde e que continue sempre nos inspirando com sua força de vontade e bom humor. Um abraço.*[image: Image may contain: 1 person, smiling, eyeglasses and closeup] Instituto de Cardiologia Page Liked · 8 hrs · Hoje é dia de celebrar a vida do nosso queridoJoão Carlos Cechella Cechella, que está completando 28 anos de transplante cardíaco e é um dos mais longevos pacientes do mundo! Em todos estes anos sempre estivemos lado a lado, dando o melhor pela causa da doação de órgãos. Parabéns, Cechella! É um orgulh... mais »

health-creating society

Aloyzio AchuttiemAMICOR - Há 4 dias
From The LancetManifesto for a healthy and health-creating society Nigel Crisp, MA et al. Published: 07 October 2016 [image: Article has an altmetric score of 130] DOI: http://dx.doi.org/10.1016/S0140-6736(16)31801-3 | [image: show]Article Info - Summary - Full Text - References Summary Jump to SectionA positive vision for health and the economyThe manifesto ActionReferences Brexit and the troubled state of the NHS call for re-thinking the UK's approach to health. The EU referendum vote reveals deep social divisions as well as presenting the country with important decisions a... mais »

Numerical ability

Aloyzio AchuttiemAMICOR - Há 4 dias
Don’t Count on Your Chickens Countingby Neuroscience News Researchers contradict the accepted view that we biologically evolved a capacity for numerical cognition. Read more of this post *Neuroscience News* | May 16, 2017 at 11:03 am | Tags: UCSD | URL: http://wp.me/p4sXNK-aDk Comment See all comments [image: Image shows a person getting a vaccination.] Nunez calls on researchers to become more precise with their terms and suggests that it could be productive to investigate “what seems to be nearly universal in human cultures and in many nonhuman animals too: a ‘quantical’ ability... mais »

Neuro-Immune Reactions to Viruses

Aloyzio AchuttiemAMICOR - Há 5 dias
Certain Immune Reactions to Viruses Cause Learning Problemsby Neuroscience News A new study reports researchers have discovered the mechanism which may cause learning disorders and memory problems as a result of the immune system's reaction to viral infections like HIV and flu. Read more of this post *Neuroscience News* | May 15, 2017 at 9:40 am | Tags: CX3CR1, CX3CR1highLY6Clow, learning impairment, Ly6C, TNFa, viruses | URL: http://wp.me/p4sXNK-aCo Comment See all comments

Richest Persons by year

Aloyzio AchuttiemAMICOR - Há 5 dias
Who's the Richest Person Your Age?This list shows the world's wealthiest people born in every year from 1917 to 1996. Combined, they are worth some $1.4 trillion

Quatro homenageados do A.T.C. em 1934

José Antonio BrenneremBrenner de Santa Maria - Há 6 dias
*Diário do Interior*, sexta-feira, 16.2.1934, p.2. Na sessão de diretoria do Avenida Tênis Clube, em 8 de dezembro de 1933, o tesoureiro, Ernesto Lang, propôs que fosse inaugurado, na sede do clube, um quadro com as fotografias dos associados João Appel Lenz, Carlos Lang, João da Costa Ribeiro e Alcides Roth, "em homenagem aos relevantes serviços daqueles consócios." João Appel Lenz, então presidente, estava em licença para tratamento de saúde, desde fins do mês anterior, e João da Costa Ribeiro, presidente em exercício, afastou-se da sessão. Assim, esses dois dirigentes ficaram ... mais »

Friday, May 19, 2017

People in order: age









https://aeon.co/videos/ageing-to-the-beat-of-their-own-drums-from-one-to-100-years-old

Sania Nishtar: WHO

Dr Sania Nishtar is the ideal person to lead WHO and we urge the world's 194 health ministers to elect her as the next Director–General (DG) in the coming World Health Assembly. Every health minister at the World Health Assembly will be aware of the wide and deep challenges facing WHO and global public health, and will be cognisant of the need to find the best leader. This is not a claim we make lightly. Many of the arguments for our claim are set out in detail in Nishtar's published manifesto,1but some of the more important points bear repeating./.../

Wednesday, May 17, 2017

World Health Statistics 2017

World Health Statistics 2017: Monitoring health for the SDGs

The World Health Statistics series is WHO’s annual compilation of health statistics for its 194 Member States.
World Health Statistics 2017 compiles data on 21 health-related Sustainable Development Goals (SDG) targets, with 35 indicators, as well as data on life expectancy. This edition also includes, for the first time, success stories from several countries that are making progress towards the health-related SDG targets.

Older physicians

Diana Swift
May 16, 2017
The sample comprised 736,537 admissions to US acute-care hospitals managed by 18,854 hospitalists. The median age of physicians was 41 years, with 10,177 physicians younger than 40 years, 8016 aged from 40 to 49 years, 3331 aged from 50 to 59 years, and 1086 aged 60 years and older.
The characteristics of the patients were comparable across physician age groups, with a mean age of approximately 80.5 years, 60% women, and approximately 83% white.
Overall 30-day mortality rate was 11.1%. After adjustment for patient and physician characteristics and hospital-specific fixed effects, the adjusted 30-day mortality rates across the four age categories were as follows: 10.8% for physicians younger than 40 years (95% confidence interval [CI], 10.7% - 10.9%), 11.1% for those aged 40 to 49 years (95% CI, 11.0% - 11.3%), 11.3% for those aged 50 to 59 years (95% CI, 11.1 - 11.5), and 12.1% for those aged 60 years and older (95% CI, 11.6% - 12.5%).
The outcomes were similar when the authors included patients treated by nonhospitalist general internists.
When stratified by patient volume, the association between physician age and patient mortality was positive for low volumes (90 - 200 admissions per year), with each 10-year age increase associated with an adjusted odds ratio for 30-day mortality of 1.19 (95% CI, 1.14 - 1.23; P < .001) and 1.06 (95% CI, 1.03 to 1.09; P < .001), respectively.
"Further research is warranted to understand exactly why low- to medium-volume older physicians have worse outcomes, and how we can solve this problem," Dr Tsugawa told Medscape Medical News.
In other study endpoints, no correlation emerged between physician age and a 30-day readmission rate of about 15% across all age groups, for an adjusted odds ratio for each additional 10 years of 1.00 (95% CI, 0.99 - 1.01; P = .82). Variations in Medicare Part B spending by physician age were significant but small, with each decade increase correlating to a cost rise of 2.4% (95% CI, 2.0% - 2.8%; P <.001). Billings ranged from $1008 for physician billings in the under-40 age category to $1071 in the 60-and-older group.
The authors point to a recent resurgence of interest in how quality of care evolves during a physician's career and how continuing medical education should be integrated into busy clinical schedules in a tolerable manner.
They note that although quality-of-care initiatives have largely focused on system-level measures, "there is increasing policy emphasis on the role of individual physicians in influencing costs and quality of care," including the value-based payment models under the Medicare Access and CHIP Reauthorization Act (MACRA).
Dr Tsugawa said these data cannot indicate whether the effect of physician age would be so pronounced among younger acute care patients. "However, it is important to note that we found that the impact of physician age was similar among patients ages 65 to 75 — relatively young patients in our sample — and among Medicare beneficiaries age 64 or younger," he told Medscape Medical News. "That suggests that similar findings may be observed if we could study a younger patient population."
In 2016, Medscape Medical News reported on another outcome study by Dr Tsugawa's group showing that elderly patients treated by female physicians had lower mortality and readmission rates than those cared for by male physicians within the same hospital. The current age-based study, however, did not tease out the gender factor, Dr Tsugawa said.
The authors and Dr Aiken have disclosed no relevant financial relationships.
BMJ. Published online May 16, 2017. ArticleEditorial
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Cardiologist Compensation Report 2017