Sunday, February 01, 2015

2691 - AMICOR 17

Finding Meaning in a Crazy World

Aloyzio AchuttiemAMICOR - Há 6 minutos
*http://us2.campaign-archive2.com/?u=13eb080d8a315477042e0d5b1&id=f2a44c2b67&e=9361f35254* Anne Lamott on How We Endure and Find Meaning in a Crazy World We live in a culture of dividedness and fragmentation of the self. When we contemplate what it takes to live a full life, we extol mindfulness and wholeheartedness. But being wholehearted is only sufficient if your heart is your whole self; being mindful is only sufficient if your mind is all you are. We are, of course, so much more expansive than our hearts and our minds and our perfect abs, or whatever fragment we choose to fixate o... mais »

Longer life?

Aloyzio AchuttiemAMICOR - Há 10 horas
*Selecionado pela AMICOR Maria Inês Reinert Azambuja* *AGING The downside of living a longer life * SCIENCE sciencemag.org 30 JANUARY 2015 • VOL 347 ISSUE 6221 517 Over the years, scientists have identified many factors that increase longevity in animal models. But do these interventions also let animals stay healthy longer, giving them an extended “healthspan”? To find out, Bansal et al. measured a range of physiological parameters over the lifetime of worms with mutations that extended their lifespans. The effect of these mutations on healthspan was variable. In fact, control worms ... mais »

Brain-to-brain communication

Aloyzio AchuttiemAMICOR - Há 17 horas
[image: TED] TALK OF THE WEEK Miguel Nicolelis: Brain-to-brain communication has arrived. How we did it 18:57 minutes · Filmed Oct 2014 · Posted Jan 2015 · TEDGlobal 2014 You may remember neuroscientist Miguel Nicolelis — he built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup. What’s he working on now? Building ways for two minds (rats and monkeys, for now) to send messages brain to brain. Watch to the end for an experiment that, as he says, will go to "the limit of your imagination." Watch now »

Capão da Canoa

Aloyzio AchuttiemAMICOR - Há 17 horas
CAPÃO DA CANOA BEACH – O ÁLBUM, POR LUIZ EDUARDO ROBINSON ACHUTTI

HBP Guidelines

Aloyzio AchuttiemAMICOR - Há 17 horas
Looser Hypertension Guidelines Could Still Save Lives, $$ Even the less aggressive 2014 targets would be better than the status quo, study shows. If new and controversial treatment recommendations for adults with hypertension were fully implemented, there would be 13,000 fewer deaths annually than if the status quo was continued, claims a new study that simulated costs over 10 years. By Parker Brown *Staff Writer, MedPage Today* If new and controversial treatment recommendations for adults with hypertension were fully implemented, there would be 13,000 fewer deaths annua... mais »

Memory and worm genomics

Aloyzio AchuttiemAMICOR - Há 18 horas
Genome-wide search reveals >750 worm genes involved in long-term memoryJanuary 25, 2015 Whole-genome expression data reveals new genes involved in long-term memory formation in worms (credit: Murphy lab) A new Princeton University study has identified more than 750 genes involved in long-term memory in the worm — part of research aimed at finding ways to retain cognitive abilities during aging, including compounds. The study takes a different approach than the recentENIGMA study, which identified genetic mutations in humans related to brain aging. The new study, published in the jour... mais »

Extending telomers

Aloyzio AchuttiemAMICOR - Há 18 horas
Scientists extend telomeres to slow cell aging A modified RNA that encodes a telomere-extending protein to cultured human cell yielded large numbers of cells for study January 26, 2015 Human chromosomes (gray) capped by telomeres (white) (credit: Wikimedia Commons) Scientists at the Stanford University School of Medicine have developed a new procedure that uses modified messenger RNA to quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are associated with aging and disease. Treated cells behave as if they are much younge... mais »

Thrombosis

Aloyzio AchuttiemAMICOR - Há 18 horas
Carbon nanotubes found to create blood clots in medical devicesJanuary 26, 2015 Scanning electron micrographs of multiwall-carbon-nanotube-modified PVC prior to (top) and after (bottom) perfusion, showing platelet aggregation (credit: Alan M. Gaffney et al./Nanomedicine) Scientists in the School of Pharmacy and Pharmaceutical Sciences in Trinity College Dublin, have discovered that using carbon nanotubes as biomaterials that come into contact with blood generates blood clots. The reason: When blood comes into contact with foreign surfaces, the blood’s protective platelets are activate... mais »

Cafeine: Astrocytes receptors

Aloyzio AchuttiemAMICOR - Há 18 horas
Targeting specific astrocyte brain-cell receptors found to boost memory in mice A drug that targets those receptors could improve memory in Alzheimer's disease January 27, 2015 Astrocytes are stained in red, the A2A receptors in green, the overlap between the two shows as yellow, and the cell nuclei are in blue (credit: Anna Orr/Gladstone Institutes) Gladstone Institutes researchers have uncovered a new memory regulator in the brain that may offer a potential treatment to improve memory in Alzheimer’s disease using a drug that targets those receptors. They found in their research* tha... mais »

Anticholinergics and dementia

Aloyzio AchuttiemAMICOR - Há 21 horas
Higher dementia risk linked to more use of common drugsJanuary 27, 2015 (Credit: iStock) A large study links a significantly increased risk for developing dementia, including Alzheimer’s disease, to taking commonly used medications with anticholinergiceffects at higher doses or for a longer time. Many older people take these medications, which include nonprescription diphenhydramine (Benadryl) and related drugs. *JAMA Internal Medicine *published the report, called “Cumulative Use of Strong Anticholinergic Medications and Incident Dementia.” It’s been known for some time that memory or ... mais »

diabetes treatment

Aloyzio AchuttiemAMICOR - Há 21 horas
Probiotic treats diabetes in rats, could lead to human remedy Lowers glucose levels by 30 percent; could be delivered as pill instead of injections January 29, 2015 This image shows a rat intestinal epithelial cell reprogrammed to express insulin (green). The cell nucleus is stained blue. (Credit: Franklin F. Duan et al./Diabetes) Imagine a pill that helps people control diabetes with the body’s own insulin to lower blood glucose levels. Cornell researchers have achieved this feat in rats by engineering human lactobacilli, a common gut bacteria, to secrete a protein that modifies inte... mais »

Deep-brain imaging

Aloyzio AchuttiemAMICOR - Há 21 horas
Deep-brain imaging reveals which nearly identical neurons are associated with specific behaviors More precise mapping of how individual neurons interact in the brain January 30, 2015 Each image is of the same exact neurons of a genetically defined group of cells. But some (left) fire while mice search for food; others (right) fire while the mice eat food. Scale bars, 100 micrometers. (Credit: Garret Stuber, PhD) Researchers at the UNC School of Medicine have used new deep-brain imaging techniques to link the activity of individual, genetically similar neurons to particular behaviors o... mais »

Design facilitando comunicação

Aloyzio AchuttiemAMICOR - Há um dia
*Referência da Dra. Ana Lúcia Robinson Achutti*Portuguesa usa o design para se comunicar com os avós que têm Alzheimer PORTAL_APRENDIZ SEX, 30/01/2015 - 08:11 Por Danilo Mekari do, Portal Aprendiz Há pelo menos 15 anos a portuguesa Rita Maldonado Branco convive com o Alzheimer. Desde quando seu avô paterno deu sinais de que os problemas de esquecimento não eram apenas pontuais – mais tarde a mesma coisa aconteceria com a avó materna –, Rita sente falta de se comunicar com eles como antigamente. A falta é tanta que usou seu conhecimento em design de comunicação para reativar os canais ... mais »

End of the World

Aloyzio AchuttiemAMICOR - Há 2 dias
[image: A gigantic mushroom cloud billowing over land in the 1940s]Doomsday Clock Set at 3 Minutes to Midnight Humanity's failure to reduce global nuclear arsenals as well as climate change prompted the Bulletin of the Atomic Scientists to advance their warning about our proximity to a potentially civilization-ending catastrophe January 24, 2015 |By Megan Gannon and LiveScience A gigantic mushroom cloud billowed over Nagasaki, Japan, when an atomic bomb was dropped on the city in 1945. *Credit: U.S. National Archives* The world is "3 minutes" from doomsday. That's the grim outlook ... mais »

New Scientist: The Brain

Aloyzio AchuttiemAMICOR - Há 2 dias
Introduction: The human brain The brain is the most complex organ in the human body, and perhaps the most remarkable. Start finding out how it works with our beginner's guide LATEST ARTICLES Portable mind-reader gives voice to locked-in people THIS WEEK: 16:00 29 January 2015 Once only possible in an MRI scanner, vibrating pads and electrode caps could soon help locked-in people communicate on a day-to-day basis/.../

Analfabetismo Político (B.Brecht)

Aloyzio AchuttiemAMICOR - Há 4 dias
*Encontrei entre meus recortes guardados estes parágrafos do Bertolt Brecht e aproveito para repassar aos amigos.*

AMRIGS

Aloyzio AchuttiemAMICOR EXTENSION - Há 4 dias
*Associação Médica do Rio Grande do Sul* Remexendo em arquivos encontrei um cartão de visitas meu como Diretor Científico da AMRIGS (trocando o "z" pelo "s" na grafia de meu nome) e meu deu vontade de ressuscitar algumas memórias daquela época. Vou postar aqui a imagem do cartão para ficar na obrigação de escrever algo mais e não ir protelando para depois. Fiz parte das diretorias presididas pelo *Osmar Pilla, Luiz Alberto Fagundes, Manoel Antônio Pitta Pinheiro de Albuquerque e Harry Graeff*. Iniciei como membro da Comissão Científica presidida pelo saudoso *Mario Rigatto*, substit... mais »

Mitochondria

Aloyzio AchuttiemAMICOR - Há 4 dias
Were Cellular Powerhouses Once Parasites?*Thomas Fuchs* Mitochondria may have started out stealing energy rather than producing it Jan 20, 2015 |By Annie Sneed Mitochondria, the organelles known to every junior high school student as “the powerhouses of the cell,” go back some two billion years. Although these energy producers were identified in the 1800s, how they became fixtures in cells is still under debate. Mitochondria's ancestor was a free-living bacterium that another single-celled organism ingested. Most biologists think that the bacterium benefited the host: in one hypothe... mais »

Rio Pardo – 1957

José Antonio BrenneremBrenner de Santa Maria - Há 6 dias
Nossa turma de estudantes da Faculdade de Arquitetura da UFRGS, quando cursava o 4º ano, fez uma viagem de estudos a Rio Pardo, em 1957, possivelmente em setembro ou outubro. A viagem foi promovida pelo Prof. João Baptista Pianca, da disciplina de Arquitetura no Brasil, para conhecer o patrimônio edificado, notadamente a Matriz N. S.ra do Rosário e a Capela de São Francisco, além da estatuaria sacra. Matriz N. Senhora do Rosário Rio Pardo é um dos mais antigos e importantes municípios da história rio-grandense, que tem suas raízes no forte Jesus, Maria e José, construído em 175... mais »

Robert Frederick Schilling (01/19/1919 - 30/09/2014)

Aloyzio AchuttiemAMICOR - Há 6 dias
*The Lancet* ‏@TheLancet 3h3 hours ago Obituary: Robert Frederick Schilling, haematologist & inventor of Schilling Test http://www.thelancet.com/pdfs/journals/ lancet/PIIS0140-6736(15)60109-X.pdf … #LancetUSA [image: Embedded image permalink]

Finding Meaning in a Crazy World

http://us2.campaign-archive2.com/?u=13eb080d8a315477042e0d5b1&id=f2a44c2b67&e=9361f35254

Anne Lamott on How We Endure and Find Meaning in a Crazy World

We live in a culture of dividedness and fragmentation of the self. When we contemplate what it takes to live a full life, we extol mindfulness and wholeheartedness. But being wholehearted is only sufficient if your heart is your whole self; being mindful is only sufficient if your mind is all you are. We are, of course, so much more expansive than our hearts and our minds and our perfect abs, or whatever fragment we choose to fixate on. But we compartmentalize our experience in this way, divide it into fragments, as if to divide and conquer it. I've written before about our resistance to speaking of the soul, of which those of us who uphold secular ideals of rationalism are especially culpable. And yet I find, over and over, that the fullest people – the people most whole and most alive – are those unafraid and unashamed of the soul.
The soul has had no greater champion in this age of fragments thanAnne Lamott – a writer of exceptional lucidity and enchantment, with a rare way of becalming our modern anxieties and ancient anguishes, from grief and gratitude to the perils of perfectionism to how we keep ourselves small with people-pleasing. In Stitches: A Handbook on Meaning, Hope and Repair (public library), Lamott lays bare the deepest, most worn yet most resilient threads of the soul and laces out of the loose ends an extraordinary lattice of assurance and grace – assurance that there is hope for awakening in ourselves "a deeper sense of immediacy or spirit or playfulness" amid the slumber of ordinary life, and for those moments when we feel like all such hope is lost, the grace of trusting "that we do endure, and that out of the wreckage something surprising will rise."/.../

Saturday, January 31, 2015

Longer life?


Selecionado pela AMICOR Maria Inês Reinert Azambuja
AGING The downside of living a longer life 
SCIENCE sciencemag.org 30 JANUARY 2015 • VOL 347 ISSUE 6221 517
Over the years, scientists have identified many factors that increase longevity in animal models. But do these interventions also let animals stay healthy longer, giving them an extended “healthspan”? To find out, Bansal et al. measured a range of physiological parameters over the lifetime of worms with mutations that extended their lifespans. The effect of these mutations on healthspan was variable. In fact, control worms had the greatest healthspan when calculated as a percentage of total lifespan. Extending the period of ill health  of an increasingly aged human population could be devastating, suggesting that researchers should focus on optimizing healthspan rather than lifespan. — LBR Proc. Natl. Acad. Sci. U.S.A. 10.1073/ pnas.1412192112 (2015)

Brain-to-brain communication


TED

Miguel Nicolelis: Brain-to-brain communication has arrived. How we did it

18:57 minutes · Filmed Oct 2014 · Posted Jan 2015 · TEDGlobal 2014
You may remember neuroscientist Miguel Nicolelis — he built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup. What’s he working on now? Building ways for two minds (rats and monkeys, for now) to send messages brain to brain. Watch to the end for an experiment that, as he says, will go to "the limit of your imagination."

Capão da Canoa



CAPÃO DA CANOA BEACH – O ÁLBUM, POR LUIZ EDUARDO ROBINSON ACHUTTI

HBP Guidelines




Looser Hypertension Guidelines Could Still Save Lives, $$

Even the less aggressive 2014 targets would be better than
the status quo, study shows.
If new and controversial treatment recommendations for adults with hypertension
were fully implemented, there would be 13,000 fewer deaths annually than if the
status quo was continued, claims a new study that simulated costs over 10 years.

Staff Writer, MedPage Today

If new and controversial treatment recommendations for adults with hypertension were fully implemented, there would be 13,000 fewer deaths annually than if the status quo was continued, claims a new
study that simulated costs over 10 years.
The new recommendations made three major changes, said the study authors:
  • A greater focus on diastolic, rather than systolic blood pressure
    for adults under 60
  • More conservative blood pressure goals for those ages 60 and over
  • More conservative blood pressure goals for patients with diabetes
    or chronic kidney disease

Memory and worm genomics

Genome-wide search reveals >750 worm genes involved in long-term memory

January 25, 2015
Whole-genome expression data reveals new genes involved in long-term memory formation in worms (credit: Murphy lab)
A new Princeton University study has identified more than 750 genes involved in long-term memory in the worm — part of research aimed at finding ways to retain cognitive abilities during aging, including compounds.
The study takes a different approach than the recentENIGMA study, which  identified genetic mutations in humans related to brain aging.
The new study, published in the journal Neuron, included many genes that had not been found previously and that could serve as targets for future research, said senior author Coleen Murphy, an associate professor of molecular biology at Princeton and the Lewis-Sigler Institute for Integrative Genomics./.../

Extending telomers

Scientists extend telomeres to slow cell aging

A modified RNA that encodes a telomere-extending protein to cultured human cell yielded large numbers of cells for study
January 26, 2015
Human chromosomes (gray) capped by telomeres (white) (credit: Wikimedia Commons)
Scientists at the Stanford University School of Medicine have developed a new procedure that uses modified messenger RNA to quickly and efficiently increase the length of human telomeres, the protective caps on the ends of chromosomes that are associated with aging and disease.
Treated cells behave as if they are much younger than untreated cells, multiplying with abandon in the laboratory dish rather than stagnating or dying. Skin cells with telomeres lengthened by the procedure were able to divide up to 40 more times than untreated cells.
The procedure will improve the ability of researchers to generate large numbers of cells for study or drug development and may lead to preventing or treating diseases of aging, the scientists say.
Telomeres are the protective caps on the ends of chromosomes, which house our genomes. In young humans, telomeres are about 8,000–10,000 nucleotides long. They shorten with each cell division, however, and when they reach a critical length, the cell stops dividing or dies. This internal “clock” makes it difficult to keep most cells growing in a laboratory for more than a few cell doublings.

Thrombosis

Carbon nanotubes found to create blood clots in medical devices

January 26, 2015
Scanning electron micrographs of multiwall-carbon-nanotube-modified PVC prior to (top) and after (bottom) perfusion, showing platelet aggregation (credit: Alan M. Gaffney et al./Nanomedicine)
Scientists in the School of Pharmacy and Pharmaceutical Sciences in Trinity College Dublin, have discovered that using carbon nanotubes as biomaterials that come into contact with blood generates blood clots.
The reason: When blood comes into contact with foreign surfaces, the blood’s protective platelets are activated, creating blood clots.
This can be catastrophic in clinical settings where extracorporeal circulation technologies are used, such as during heart-lung bypass, in which the blood is circulated in PVC tubing outside the body.
Their findings are reported in an open-access paper published in the January issue of the journal Nanomedicine./.../

Cafeine: Astrocytes receptors

Targeting specific astrocyte brain-cell receptors found to boost memory in mice

A drug that targets those receptors could improve memory in Alzheimer's disease
January 27, 2015
Astrocytes are stained in red, the A2A receptors in green, the overlap between the two shows as yellow, and the cell nuclei are in blue (credit: Anna Orr/Gladstone Institutes)
Gladstone Institutes researchers have uncovered a new memory regulator in the brain that may offer a potential treatment to improve memory in Alzheimer’s disease using a drug that targets those receptors.
They found in their research* that decreasing the number of A2A adenosine receptors in astrocyte brain cells improved memory in healthy mice. It also prevented memory impairments in a mouse model of Alzheimer’s disease.
The findings were published Monday (Jan. 26) in Nature Neuroscience./.../

Anticholinergics and dementia

Higher dementia risk linked to more use of common drugs

January 27, 2015
(Credit: iStock)
A large study links a significantly increased risk for developing dementia, including Alzheimer’s disease, to taking commonly used medications with anticholinergiceffects at higher doses or for a longer time.
Many older people take these medications, which include nonprescription diphenhydramine (Benadryl) and related drugs.
JAMA Internal Medicine published the report, called “Cumulative Use of Strong Anticholinergic Medications and Incident Dementia.”
It’s been known for some time that memory or concentration problems in the elderly might be caused by common medications used to treat insomnia, anxiety, itching or allergies, according to a 2012 study reported by KurzweilAI.

diabetes treatment

Probiotic treats diabetes in rats, could lead to human remedy

Lowers glucose levels by 30 percent; could be delivered as pill instead of injections
January 29, 2015
This image shows a rat intestinal epithelial cell reprogrammed to express insulin (green). The cell nucleus is stained blue. (Credit: Franklin F. Duan et al./Diabetes)
Imagine a pill that helps people control diabetes with the body’s own insulin to lower blood glucose levels.
Cornell researchers have achieved this feat in rats by engineering human lactobacilli, a common gut bacteria, to secrete a protein that modifies intestinal cells to produce insulin..
A 2003 study led by Atsushi Suzuki of the University of Tsukuba, Japan, first demonstrated that when exposed to a protein called Glucagon-like peptide 1 (GLP-1), intestinal epithelial cells (which cover the guts) are converted into insulin-producing cells.

Deep-brain imaging

Deep-brain imaging reveals which nearly identical neurons are associated with specific behaviors

More precise mapping of how individual neurons interact in the brain
January 30, 2015
Each image is of the same exact neurons of a genetically defined group of cells. But some (left) fire while mice search for food; others (right) fire while the mice eat food. Scale bars, 100 micrometers. (Credit: Garret Stuber, PhD)
Researchers at the UNC School of Medicine have used new deep-brain imaging techniques to link the activity of individual, genetically similar neurons to particular behaviors of freely moving mice.
For the first time ever, scientists watched as one neuron was activated when a mouse searched for food while a nearly identical neuron next to it remained inactive; instead, the second neuron only became activated when the mouse began eating./.../

Friday, January 30, 2015

Design facilitando comunicação

Referência da Dra. Ana Lúcia Robinson Achutti

Portuguesa usa o design para se comunicar com os avós que têm Alzheimer

Por Danilo Mekari do, Portal Aprendiz
Há pelo menos 15 anos a portuguesa Rita Maldonado Branco convive com o Alzheimer. Desde quando seu avô paterno deu sinais de que os problemas de esquecimento não eram apenas pontuais – mais tarde a mesma coisa aconteceria com a avó materna –, Rita sente falta de se comunicar com eles como antigamente. A falta é tanta que usou seu conhecimento em design de comunicação para reativar os canais de troca com os avós./.../

Thursday, January 29, 2015

End of the World

A gigantic mushroom cloud billowing over land in the 1940s

Doomsday Clock Set at 3 Minutes to Midnight

Humanity's failure to reduce global nuclear arsenals as well as climate change prompted the Bulletin of the Atomic Scientists to advance their warning about our proximity to a potentially civilization-ending catastrophe 


A gigantic mushroom cloud billowed over Nagasaki, Japan, when an atomic bomb was dropped on the city in 1945. 
Credit: U.S. National Archives
The world is "3 minutes" from doomsday.
That's the grim outlook from board members of The Bulletin of the Atomic Scientists. Frustrated with a lack of international action to address climate change and shrink nuclear arsenals, they decided today (Jan. 22) to push the minute hand of their iconic "Doomsday Clock" to 11:57 p.m.
It's the first time the clock hands have moved in three years; since 2012, the clock had been fixed at 5 minutes to symbolic doom, midnight. [End of the World? Top Doomsday Fears]/.../