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Tuesday, June 19, 2018

Pharmacology 2017/8



 
 
Not Just for Pharmacologists

The broad coverage of the Concise Guide includes sections of interest to: physiologists and health scientists, cell biologists and those working in the life sciences, biochemists and those in chemistry.

Published as a special issue in the British Journal of Pharmacology every 2 years, the Concise Guide to PHARMACOLOGY provides brief overviews of the key properties of over 1,700 human drug targets and their pharmacology and is a view of the data in the IUPHAR/BPS Guide to PHARMACOLOGY that allows side by side comparison of members of families of drug targets.

Sunday, June 17, 2018

Saúde ou Doença?

Proposta de temas para pensar e discutir do AMICOR Roni Quevedo:
Saúde! de quem? que saúde?
Há muito tempo que o investimento em saúde é direcionado e centralizado na doença, inspirado na Medicina Flechneriana, centrada na enfermidade, no Hospital e na droga alopática, no medicamento industrializado. Nosso conceito de Saúde ainda não está totalmente claro, límpido, sólido...saudável enfim!
Constatações:
  • - aqui, no RS, as pequenas e médias cidades têm muito mais drogarias do que padarias;
  • - muitos medicamentos são comercializados sem a necessidade da indicação formal do profissional da saúde, estando livres de receituário;
  • - com muita frequência vemos promoção tipo compra um leva dois;
  • - medicamentos em “oferta” para queima de estoque;
  • - entre os dias 05 e 10 de cada mês, a população vai as drogarias fazer “rancho” de medicamentos, refazer o estoque de drogas que talvez nunca vá utilizar e, na fila do caixa ficam comparando as conquistas;
  • - medicamentos com custo tão elevados que serão pagos em várias prestações;
  • - “liquidação” / “saldo” de medicamentos encalhados, aqueles que “saem de moda”;
  • - ofertas irrecusáveis, tipo compra uma droga para tratar uma doença leva e, de “oferta” por “venda casada” leva outro medicamento para tratar outra enfermidade que o cliente nem sabe o que significa...
  • - não raro o atendente “receita” medicamento(s): para uma “febrícula” sem importância, (deve ser um “antitermículo”), um comprimidinho para uma dorzinha qualquer, ou um “laxantezinho” para uma “prisãozinha de ventre” aleatória...  
  • - a drogaria faz chamada pelo microfone em bom som “aproveite que está em oferta, freguês!”.
  • - medicamentos são comercializados por até 90% de descontos?!, para quem pedir, se não, paga o preço “real”.

Aí, de volta para casa, faz uma faxina no depósito, os medicamentos vencidos são jogados no lixo, no vaso sanitário que voltarão de alguma forma através da água tratada (?)...
Sem considerar que muitos tratamentos são preconizados pelo vizinho inapto, pelo balconista leigo, pela conversa no elevador, a escuta na fila do ônibus, ou pelo palpite de alguém que já usou...
Estamos verdadeiramente pouco preocupados com a Saúde. Estão aí as mazelas. O sistema de prevenção é precário, tanto que o tabaco é a primeira causa de morte evitável no mundo. A segunda causa é o álcool e a terceira o fumo passivo.
Um percentual preocupante de internações hospitalares devem -se ao uso inadequado de medicamentos e/ou suas reações adversas e efeitos colaterais.
As Associações Médicas são motivadas/construídas por enfermidades. Eles não se reúnem por saúde, mas sim por doenças, veja:  Sociedade Brasileira de Cefaleia,
Associação Brasileira do Déficit de Atenção, Sociedade Brasileira de Hipertensão, etc.
Somos tratados por partes, por segmentos, por órgãos isolados. Ainda não percebemos que o adoecimento é da Pessoa.
Em suma, humanos saudáveis não geram lucro…


Roni Quevedo.-

Saturday, June 16, 2018

2873 - AMICOR 21

Cirurgia Cardíaca Pediátrica

Aloyzio AchuttiemAMICOR - Há uma hora
O *Hospital Moinhos de Vento* e *Renato Abdala Karam Kalil* estão de parabéns! A Inauguração do *Centro de Cirurgia Cardíaca e Cardiologia Pediátrica* no dia de ontem me fizeram lembrar: o *Ambulatório Cardiopulmonar da Enfermaria 38 da Santa Casa* (na segunda metade da décadqa de 50) do qual fui diretor; do Serviço do Prof. *Eduardo Faraco*, do *Flávio Freitas*, *Adão do Valle Mattos*, do *Instituto Sábato D' Angelo*, *Hugo Felipozzi e Adauto Barbosa Lima*, da Equipe de Cirurgia Cardíaca daqui, liderada pelo *Cid Nogueira*, da Enfermaria 30, das cirurgias de crianças de baixo peso ... mais »

Netos Eduardo e Júlia

Aloyzio AchuttiemAMICOR - Há 6 horas
Nosso neto *Eduardo Belardinelli Achutti *que está morando em Siena (IT), estudando e jogando futebol, está de férias e veio nos visitar ontem. Foto de ontem com *Júlia*, nossa primeira neta.

How to Internet

Aloyzio AchuttiemAMICOR - Há 7 horas
How to Internet A guided tour through the past, present, and future of logging on [image: Go to the profile of Jenny Odell] Jenny Odell Follow Dec 20, 2016 At my job teaching college students, I’m occasionally mistaken for one. I’ve found that a good way to make students take me seriously on the first day is to mention that I remember a time *before the internet*. Of course that’s not true given a precise interpretation of what the internet actually is. But I’m certainly old enough to remember PSA-like videos coaxing the casual newbie into the exciting, if intimidating, world of cyb... mais »

How to read

Aloyzio AchuttiemAMICOR - Há 7 horas
*How to Read the Right Way: A Complete Guide* [image: Go to the profile of Melissa Chu] Melissa ChuFollow I write about living better, creating great work, and making an impact. Get your guide to achieving your goals at http://jumpstartyourdreamlife.com/welcome. May 15 Reading is dead. The nature of books has evolved. Society and technology have changed. Forcibly, our approach to reading has taken on new forms to accommodate a different way of life. The question is: For better or worse? Although books give us new ideas, spark discussions, and explore topics in detail, the same informat... mais »

Traumatic Memories

Aloyzio AchuttiemAMICOR - Há 7 horas
Neurons that Rewire Traumatic Memoriesby Neuroscience News [image: the dentate gyrus in the brain] Cross section of brain showing the dentate gyrus (“Gyrus dentatus” at bottom center). NeuroscienceNews.com image is credited to Henry Gray, Anatomy of the Human Body (1918). Researchers have identified neurons in the dentate gyrus that help to reprogram lasting traumatic memories. Read more of this post *Neuroscience News* | June 16, 2018 at9:33 am | Tags: EPFL, traumatic memories | URL: https://wp.me/p4sXNK-cVT

IBM

To day *1911:* *International Business Machine Corporation (IBM)*, a leading American computer manufacturer, was incorporated.

Joyce Carol Oates

Aloyzio AchuttiemAMICOR - Há 14 horas
[image: Joyce Carol Oates, 1992.] *Joyce Carol Oates* American writer Joyce Carol Oates, noted for her vast literary output in a variety of styles and genres and for her particularly effective depictions of violence and evil in modern society, was born on this day in 1938.

Coronary artery disease

Aloyzio AchuttiemAMICOR - Há um dia
Estimated costs of hospitalization due to coronary artery disease attributable to familial hypercholesterolemia in the Brazilian public health system - May 2018 - DOI: - 10.20945/2359-3997000000030 - License - CC BY 4.0 - Luciana R Bahia - [image: Roger dos Santos Rosa]Roger dos Santos Rosa - [image: Raul D. Santos]Raul D. Santos - [image: Denizar Vianna Araujo]Denizar Vianna Araujo Abstract Objective: Cardiovascular diseases are the leading cause of death in Brazil, imposing substantial economic burden on the health care system. Familial hypercholest... mais »

Periodic table

Aloyzio AchuttiemAMICOR - Há 2 dias
Battle for the periodic table In 2015, four new elements were added to the periodic table with great fanfare — nihonium (atomic number 113), moscovium (115), tennessine (117) and oganesson (118). But some researchers complain the announcement was premature: these superheavy elements are difficult to produce and incredibly short-lived, so verifying their discovery is tricky. Now, chemists and physicists are at odds over who should be the legitimate custodians of the periodic table. Nature | 8 min read

Med-diet

Aloyzio AchuttiemAMICOR - Há 2 dias
Mediterranean-diet paper rises again Grab your olive oil: a huge study about whether a Mediterranean diet helps to prevent heart disease has been republished. The *New England Journal of Medicine* is also correcting five other papers, one year after a controversial review suggested that many published clinical trials contain statistical errors. Anaesthesiologist John Carlisle used a computer program to find cases in which study volunteers might not have been as randomly assigned as was claimed. In the Mediterranean-diet paper, a re-analysis confirmed the original conclusion. Science... mais »

Microglia and Alzheimer's D.

Aloyzio AchuttiemAMICOR - Há 2 dias
Is “Friendly Fire” in the Brain Provoking Alzheimer's Disease?Scientists want to combat dementia and neurodegeneration by keeping the brain’s immune system from going rogueNeuroscientist Michael Heneka knows that radical ideas require convincing data. In 2010, very few colleagues shared his belief that the brain’s immune system has a crucial role in dementia. So in May of that year, when a batch of new results provided the strongest evidence he had yet seen for his theory, he wanted to be excited, but instead felt nervous. +++++++++++++++++++++ Even so, the idea has sparked the inter... mais »

Neural Network

Aloyzio AchuttiemAMICOR - Há 2 dias
How to build your own Neural Network from scratch in Python A beginner’s guide to understanding the inner workings of Deep Learning James Loy in Towards Data Science6 min read

Statistics

Aloyzio AchuttiemAMICOR - Há 2 dias
The 10 Statistical Techniques Data Scientists Need to Master James Le in Towards Data Science15 min read Regardless of where you stand on the matter of Data Science sexiness, it’s simply impossible to ignore the…

Obesity

Aloyzio AchuttiemAMICOR - Há 2 dias
A short primer on how to Lose Weight — What to Eat and When to Eat Here’s a startling truth. I can make you fat. Actually, I can make anybody fat. How? I simply prescribe… Dr. Jason Fung7 min read

FIFA

Aloyzio AchuttiemAMICOR - Há 2 dias
[image: World Cup 2018 - Day 1]

Ildefonso Brenner – 13 de junho de 1862

José Antonio BrenneremBrenner de Santa Maria - Há 3 dias
Hoje, 13 de junho de 2018, aos 156 anos do nascimento de Ildefonso Brenner, meu avô materno, lembro que ele nasceu em Santa Maria filho primogênito do imigrante alemão Franz Karl Brenner e da santa-mariense Christiana Hoffmeister Brenner. O pai se fixara na cidade em 1859 com alfaiataria e casa comercial. Em sua Confirmação, em Ellweiler/Hunsrück, em 20.11.1845, Franz Karl recebera sua Bíblia, como era costume na confissão luterana. Na primeira folha em branco, ele registrou o nascimento dos filhos. No primeiro registro, ele escreveu: *Ildefons Antonio Brenner* * Geboren den ... mais »

Exosomes : Alzheimer

Aloyzio AchuttiemAMICOR - Há 3 dias
New Mechanism by Which Alzheimer’s Spreads Through the Brainby Neuroscience News According to researchers, exosomes can transport toxic aggregates of amyloid beta to new neurons in the brain. Read more of this post *The waste-management system of the cell appears to play an important role in the spread of Alzheimer’s disease in the brain. A new study has focused on small membrane-covered droplets known as “exosomes”. It was long believed that the main task of exosomes was to help the cell to get rid of waste products. In simple terms, they were thought of as the cell’s rubbish bags.... mais »

Emotion Neural Circuit

Aloyzio AchuttiemAMICOR - Há 3 dias
Neural Circuit Mechanisms of Emotion Identifiedby Neuroscience News [image: amygdala nuerons]CRH neurons (red) in the amygdala. NeuroscienceNews.com image is credited to MPI of Psychiatry. Researchers shed light on the mechanisms behind the anxiolytic CRH circuit in the ventral tegmental area of the brain. Read more of this post

Salve 13 de junho de 2018!

Aloyzio AchuttiemAMICOR - Há 3 dias
Em 1932 com um aninho

Empathy and Music Process

Aloyzio AchuttiemAMICOR - Há 4 dias
Higher Empathy People Process Music Differently in the Brainby Neuroscience News Researchers report people with higher empathy process music with greater involvement in the brain's reward system and areas of the brain associated with social information processing. Read more of this post[image: brain scans taken while people listened to music] The areas of the brain for reward and social awareness uniquely activate in people with higher empathy when they listen to music. The contrast that best demonstrates the key result is the bottom series of brain scan slices, where the Familiar a... mais »

Empathy and Music Process

Aloyzio AchuttiemAMICOR - Há 4 dias
Higher Empathy People Process Music Differently in the Brainby Neuroscience News Researchers report people with higher empathy process music with greater involvement in the brain's reward system and areas of the brain associated with social information processing. Read more of this post

Baby Pregnant Mother's attitude

Aloyzio AchuttiemAMICOR - Há 4 dias
Mother’s Attitude Towards Baby During Pregnancy May Have Implications for Child’s Developmentby Neuroscience News A new study reports mothers who feel more connected with their baby during pregnancy are more likely to have positive interactions with the infant when it is born. This can have a positive effect on the child's development. Read more of this post

A1c Best Target

Aloyzio AchuttiemAMICOR - Há 4 dias
May 30, 2018 For Patients With Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? Jennifer Abbasi Article Information JAMA. Published online May 30, 2018. doi:10.1001/jama.2018.5420 Medical organizations are at odds over new guidance that recommends easing hemoglobin A1C (HbA1c) targets for patients with type 2 diabetes. The updated guidance statement from the American College of Physicians (ACP), which focuses on glycemic control with medications, says clinicians should personalize goals and aim to achieve an HbA1c level of between 7% and 8% for most patients with type 2 diabetes... mais »

GBD US 1990-2016

Aloyzio AchuttiemAMICOR - Há 4 dias
April 10, 2018 The State of US Health, 1990-2016Burden of Diseases, Injuries, and Risk Factors Among US States The US Burden of Disease Collaborators Article Information JAMA. 2018;319(14):1444-1472. doi:10.1001/jama.2018.0158 editorial comment icon Editorial Comment related articles icon Related Articles author interview icon Interviews - - - - - - Audio Interview(53:27) US Burden of Diseases, Injuries, and Disease Risk Factors, 1990-2016 Key Points *Question* How have the levels and trends of burden of diseases, injuries, and risk factors in the Uni... mais »

Flu

Aloyzio AchuttiemAMICOR - Há 4 dias
[image: newsletter image] NEWS IN BRIEF If you thought the most recent flu season was bad, you were right Jun 08 2018 12:17 PM The recent U.S. flu season was classified as highly severe overall, the third time since 2003 that the seasonal outbreak has earned that designation.

Namorados

Aloyzio AchuttiemAMICOR - Há 4 dias
Estamos em 1955: com minha* namorada Valderês Antonietta Robinson*. Eu havia enviado a foto junto com a participação de noivado para nosso amigo holandês *André J. Nuyten* que morara comigo na Casa da JUC (pensão) e fora embora para o Rio de Janeiro pouco tempo antes. Havia perdido o contato com ele, mas fomos re-encontrá-lo em 1997 quando fizemos 40 anos de casados, em Belingham (Estado de Washington) na fronteira com o Canadá. Lá ele me devolveu a recordação. Pena que ele faleceu mo ano passado (abraço para a viuva Tatiana), mas namorados, ainda estamos bem vivos...

Literature

Aloyzio AchuttiemAMICOR - Há 4 dias
There Are Two Ways to Read - One Is Useless Right, wrong, and the value of reading. Zat Rana in Personal Growth7 min read

CVD Risk

Aloyzio AchuttiemAMICOR - Há 4 dias
*Circulation*‏ @CircAHA 17h17 hours ago More A A conceptual framework for addressing residual atherosclerotic cardiovascular disease risk in the era of precision medicine. Learn more: http://ow.ly/n1Or30krG5H conceptual framework for addressing residual atherosclerotic cardiovascular disease risk in the era of precision medicine. Learn more: http://ow.ly/n1Or30krG5H

NORTH KOREA

Aloyzio AchuttiemAMICOR - Há 4 dias
the HIDDEN HISTORY of *NORTH **KOREA * Welcome to *Hidden History*, a new monthly newsletter from Narratively exploring the nuanced, obscure, and oft-forgotten histories of a topical person, place, or event. For our debut edition, we're venturing deep into North Korea—spotlighting stories that offer a lesser-known context to today's summit. Want more Hidden History? Sign up!

Guidelines

Aloyzio AchuttiemAMICOR - Há 5 dias
Read the latest updates to clinical practice guidelines and recommendations. *View Key Guidelines for June 2018:* - Alcohol-Related Liver Disease - Deprescribing Benzodiazepines for Insomnia - Hepatitis E - Essential Diagnostic Tests - Colorectal Cancer Screening - Exercise for Cancer Patients - Soft Tissue Sarcoma - GI Stromal Tumors - Soft Tissue/Visceral Sarcomas - Hodgkin Lymphoma - Head and Neck Cancers - Neuropathic Pain Pharmacotherapy - Magnetoencephalography and Brain Function - Hypertension in Pregnancy - Heart Health in Ob/Gyn Visits ... mais »

Aggressivity

Aloyzio AchuttiemAMICOR - Há 5 dias
What Makes Aggressive Mice So Violent?by Neuroscience News [image: neurons are shown] Aggressive behavior and the motivation to act aggressively have distinct molecular bases, according to a study of male mice published in JNeurosci. This finding suggests the possibility of reducing aggression by targeting a protein associated with addiction in a reward region of the brain. NeuroscienceNews.com image is credited to Hossein Aleyasin. Targeting a protein associated with addiction could help reduce aggression levels, researchers report. Read more of this post *Neuroscience News* | June 1... mais »

Para quando a hora chegar

Aloyzio AchuttiemAMICOR - Há 6 dias
*Artigo do Dr, Fernando Robinson Neubarth - primo da Dra. Valderês - no último número do Boletim de Reumatologia. (clicando na imagem deve aumentar e permitir a leitura)*

Regular physical activity

Aloyzio AchuttiemAMICOR - Há 6 dias
*Recomendado por Cristianne Maria Famer Rocha* http://www.who.int/ncds/prevention/physical-activity/gappa/ 'Regular physical activity is proven to help prevent and treat noncommunicable diseases (NCDs) such as heart disease, stroke, diabetes and breast and colon cancer. It also helps prevent hypertension, overweight and obesity and can improve mental health, quality of life and well-being. Yet, much of the world is becoming less active. WHO has developed a new global action plan to help countries scale up policy actions to promote physical activity. It responds to the requests by co... mais »

We Could and Should All Write

Aloyzio AchuttiemAMICOR - Há 6 dias
Six Books We Could and Should All Write By Anthony Madrid June 6, 2018 Let’s make sure we’re all understanding each other. I’m not talking about novels and plays and poems. And I’m definitely not talking about great novels and plays and poems. It’s pointless to tell people to write stuff like that. Even the ones who want to can’t. And of course, most people don’t even want to. My topic is different. It’s books *anybody* could write. Every single thing I’m about to describe, you wouldn’t need any talent to produce it. You wouldn’t need any talent, and you wouldn’t need any understand... mais »2873