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Monday, October 31, 2016

Dudley Johnson died (86 years old)

Referência da AMICOR Maria Inês Reinert Azambuja
Dr. Johnson, who applied crocheting and needlecraft skills, went on to perform more than 8,500 bypass operations over four decades.W. Dudley Johnson, Heart Bypass Surgery Pioneer, Dies at 86
By SAM ROBERTS
Dr. Johnson, who applied crocheting and needlecraft skills, went on to perform more than 8,500 bypass operations over four decades.

Sunday, October 30, 2016

psychobiotics

The current state of psychobiotics: what do we know?

Best time to exercise?

Circadian rhythms: What is the best time of day to exercise?

Memory Capacity

Brain's Memory Capacity 10X More Than Previously Thought

The Lancet Public Health

The Lancet Public Health first issue! Here:

2786 - AMICOR 19

Sugar and Brain

Aloyzio AchuttiemAMICOR - Há 12 segundos
Why Sugar Is So Much Worse For Teenagers’ Brains Guest October 27, 2016 The rate of obesity is increasing worldwide and the increase has been particularly dramatic in young people. Young people are the greatest consumers of high-energy, sugary and fat-laden “junk” foods and sweetened drinks. The heightened metabolism and rapid growth during puberty can protect against obesity. However, easy access to cheap junk foods and increasingly sedentary lifestyles outweighs the protection from growth spurts. Diets high in refined sugar and saturated fat not only contribute to weight gain and ... mais »

Stem cells Neurons

Aloyzio AchuttiemAMICOR - Há 24 minutos
Neurons from stem cells replace damaged neurons, precisely rewiring into the brainOctober 29, 2016 [image: Neuronal transplants (blue) connect with host neurons (yellow) in the adult mouse brain in a highly specific manner, rebuilding neural networks lost upon injury. Picture: Sofia Grade (credit: LMU/Helmholtz Zentrum München)] Embryonic neural stem cells transplanted into damaged areas of the visual cortex of adult mice were able to differentiate into pyramidal cells, forming normal synaptic connections, responding to visual stimuli, and integrating into neural networks, researcher... mais »

Moacyr Scliar

Aloyzio AchuttiemAMICOR - Há 40 minutos
*Coletânea a partir do Blog AMICOR* [image: Editoria de arte] No dia do Médico, em 18 de outubro p.p.a Academia Sul-Riograndense de Medicina promoveu uma palestra do Acadêmico *Dr.* *Blau Souza* sobre nosso escritor e sanitarista prematuramente falecido. O coordenador foi o *Dr. Rogério Xavier* e estava também presente a *Sra. Judith Scliar,* viúva do homenageado. Lembrou-nos que no próximo ano ele completaria 80 anos e, a propósito, estão sendo planejadas várias atividades relacionadas. Sua reconhecida obra literária tem sido bastante prestigiada, merecendo ainda mais destaque sua co... mais »

A Arte de Mentir

Aloyzio AchuttiemAMICOR - Há 5 horas
ZH de 29/10/2016 Relacionado com o assunto publicado na postagem do dia 26/10 p.p.

Toxic Tau

Aloyzio AchuttiemAMICOR - Há um dia
Structure of Toxic Tau Aggregates Determines Type of Dementia, Rate of Progression NEUROSCIENCE NEWSOCTOBER 28, 2016 F *Summary: A new study may help shed light on the diversity of dementias linked to tau protein aggregation.* *Source: UT Southwestern Medical Center.* *The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O’Donnell Jr. Brain Institute.* The research helps explain the diversity ... mais »

150 anos da SOCEPE desde o Deutscher Hilfsverein

José Antonio BrenneremBrenner de Santa Maria - Há um dia
A migração de alemães e descendentes para Santa Maria, desde as antigas colônias da região de São Leopoldo, começou no início da década de 1830 e continuou durante a Guerra dos Farrapos. Na florescente povoação santa-mariense, os alemães que, durante o conflito, garantiram as atividades de comércio e produção, mantiveram sua hegemonia em tempos de paz. Na época de sua emancipação política, em 1858, Santa Maria era visivelmente alemã em quase todas as atividades: comerciantes, alfaiates, curtidores, lombilheiros, ferreiros, pedreiros, ourives, sapateiros, marceneiros etc. Isso atrai... mais »

Neurogenesis and Breast Cancer

Aloyzio AchuttiemAMICOR - Há um dia
Protein Associated With Growth of Breast Cancer Essential for Production of New Neurons NEUROSCIENCE NEWSOCTOBER 28, 2016 *Summary: Researchers report AP2gamma, a protein associated with the growth of breast cancer tumors, plays a vital role in the regulation of hippocampal neurogenesis.* *Source: University of Minho.* *Protein originally known to promote the growth of breast cancer cells has been found to be essential for the production of new neurons in the adult brain.* Contrary to what was previously assumed, the notion that the adult brain has the ability to generate new neurona... mais »

Internet Trends by vpnMentor

Aloyzio AchuttiemAMICOR - Há um dia
Internet Trends, stats & facts in the U.S. and Worldwide 2016 [image: logo] The following collection of charts represents the most trusted research and the most recent data on major internet trends. Feel free to use the charts included here on your post on Internet World Usage Statistics, and do share it on social networks. While dedicated to vpns and online privacy issues, vpnMentor also wants to be your resource for Internet trends and data. As a result, we have scoured the most trusted researchers’ sites to present the following series of charts. Grouped by general topic, the inform...mais »

Halloween

Aloyzio AchuttiemAMICOR - Há 2 dias
*From *Delanceyplace.com *In today's encore excerpt -* the origins of Halloween: "Halloween's origins date back to the ancient Celtic festival of Samhain (pronounced sow-in). The Celts, who lived 2,000 years ago in the area that is now Ireland, the United Kingdom and northern France, celebrated their new year on November 1. This day marked the end of summer and the harvest and the beginning of the dark, cold winter, a time of year that was often associated with human death. Celts believed that on the night before the new year, the boundary between the worlds of the living and the dea... mais »

Human Development Report

Aloyzio AchuttiemAMICOR - Há 3 dias
Global Launch of 2015 Human Development Report For the very first time, The Human Development Report is available in a unique web version. The web version of the *Human Development Report 2015: Work for Human Development* contains interactive features that provide enhanced functionality and enable information sharing in our interconnected world.

Mentira

Aloyzio AchuttiemAMICOR - Há 3 dias
How lying takes our brains down a 'slippery slope'Telling small lies desensitizes our brains to the associated negative emotions and may encourage us to tell bigger lies in futureDate:October 24, 2016Source:University College LondonSummary:Telling small lies desensitizes our brains to the associated negative emotions and may encourage us to tell bigger lies in future, reveals new research. Researchers have shown that self-serving lies gradually escalate, and they have revealed how this happens in our brains. *Credit: © pathdoc / Fotolia* Telling small lies desensitises our brains to t... mais »

Reitoria da UFCSPA

Aloyzio AchuttiemAMICOR - Há 4 dias
Unindo Caminhos with Lucia Pellanda and Aloyzio Achutti. 8 hrs · "É com emoção e entusiasmo que apoio e recomendo a candidatura da Professora Lúcia Campos Pellanda para a Reitoria da Universidade Federal de Ciências da Saúde de Porto Alegre. Conheço sua capacidade e desempenho profissional desde meu tempo de professor da Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (no século passado). Inicialmente na Assessoria Científica e Departamento de Epidemiologia, e a seguir na prática, docência, divulgação, administração de serviço, e pesquisa, especialmente em Cardi... mais »

Sleep Loss and Microbiota

Aloyzio AchuttiemAMICOR - Há 4 dias
New post on *Neuroscience News* Sleep Loss Tied to Gut Microbiota Changes in Humansby Neuroscience News A new study reports sleep loss can lead to alterations in gut bacteria that have previously been linked to diabetes and obesity in humans. Read more of this post *Abstract* *Gut Microbiota and Glucometabolic Alterations in Response to Recurrent Partial Sleep Deprivation in Normal-weight Young Individuals* *Objective* Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including in... mais »

Sugar and Brain

Why Sugar Is So Much Worse For Teenagers’ Brains

The rate of obesity is increasing worldwide and the increase has been particularly dramatic in young people. Young people are the greatest consumers of high-energy, sugary and fat-laden “junk” foods and sweetened drinks.
The heightened metabolism and rapid growth during puberty can protect against obesity. However, easy access to cheap junk foods and increasingly sedentary lifestyles outweighs the protection from growth spurts.
Diets high in refined sugar and saturated fat not only contribute to weight gain and associated health issues, but also have a profoundly detrimental impact on brain function.
It is known excessive consumption of junk foods damage areas of the brain essential for learning and memory processes. Neurons in brain regions, including the hippocampus, that encodes memories, no longer work efficiently, leading to poorer learning.
This is of great concern as adolescence is a critical formative period for learning about the world. Adolescence is also a time of newly found independence, including food choices./.../

Stem cells Neurons

Neurons from stem cells replace damaged neurons, precisely rewiring into the brain

October 29, 2016
Neuronal transplants (blue) connect with host neurons (yellow) in the adult mouse brain in a highly specific manner, rebuilding neural networks lost upon injury. Picture: Sofia Grade (credit: LMU/Helmholtz Zentrum München)
Embryonic neural stem cells transplanted into damaged areas of the visual cortex of adult mice were able to differentiate into pyramidal cells, forming normal synaptic connections, responding to visual stimuli, and integrating into neural networks, researchers at LMU Munich, the Max Planck Institute for Neurobiology in Martinsriedand the Helmholtz Zentrum München have demonstrated.
The adult human brain has very little ability to…read more

Moacyr Scliar

Coletânea a partir do Blog AMICOR
Editoria de arte
No dia do Médico, em 18 de outubro p.p.a Academia Sul-Riograndense de Medicina promoveu uma palestra do Acadêmico Dr. Blau Souza sobre nosso escritor e sanitarista prematuramente falecido. O coordenador foi o Dr. Rogério Xavier e estava também presente a Sra. Judith Scliar, viúva do homenageado. Lembrou-nos que no próximo ano ele completaria 80 anos e, a propósito, estão sendo planejadas várias atividades relacionadas.
Sua reconhecida obra literária tem sido bastante prestigiada, merecendo ainda mais destaque sua contribuição para Saúde Pública. Trabalhei com ele na Secretaria da Saúde e Meio Ambiente do Estado, onde nos deu apoio e incentivo nos Programas de Estudo Epidemiológico, Prevenção e Controle de Doenças Crônicas e seus Fatores de Risco.
Reuni a partir do Blog AMICOR diversas referências (alguns são escritos meus e outros colecionados) que podem ser consultadas a partir do link abaixo

Saturday, October 29, 2016

A Arte de Mentir

ZH de 29/10/2016 pag 36
Relacionado com o assunto publicado na postagem do dia 26/10 p.p.


O link a seguir deve dar acesso ao texto como documento do Google Drive

https://docs.google.com/document/d/1tybQjpP5I7IlRE8ZmL4JI_nL-G3-Y4PWoLzLjKltowc/edit?usp=sharing

Friday, October 28, 2016

Toxic Tau

Structure of Toxic Tau Aggregates Determines Type of Dementia, Rate of Progression



Summary: A new study may help shed light on the diversity of dementias linked to tau protein aggregation.
Source: UT Southwestern Medical Center.
The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O’Donnell Jr. Brain Institute.
The research helps explain the diversity of dementias linked to tau protein aggregation, which destroys brain cells of patients with Alzheimer’s and other neurodegenerative syndromes. The study also has implications for earlier and more accurate diagnoses of various dementias through definition of the unique forms of tau associated with each.
“In addition to providing a framework to understand why patients develop different types of neurodegeneration, this work has promise for the development of drugs to treat specific neurodegenerative diseases, and for how to accurately diagnose them. The findings indicate that a one-size-fits-all strategy for therapy may not work, and that we have to approach clinical trials and drug development with an awareness of which forms of tau we are targeting,” said study author Dr. Marc Diamond, founding Director of the Center for Alzheimer’s and Neurodegenerative Diseases, and Professor of Neurology and Neurotherapeutics with the O’Donnell Brain Institute at UT Southwestern Medical Center.

Neurogenesis and Breast Cancer

Protein Associated With Growth of Breast Cancer Essential for Production of New Neurons


Summary: Researchers report AP2gamma, a protein associated with the growth of breast cancer tumors, plays a vital role in the regulation of hippocampal neurogenesis.
Source: University of Minho.
Protein originally known to promote the growth of breast cancer cells has been found to be essential for the production of new neurons in the adult brain.
Contrary to what was previously assumed, the notion that the adult brain has the ability to generate new neuronal cells throughout life is now well established. This process, known as neurogenesis, participates in different brain functions, such as in the production and storage of new memories, or in the very definition of the emotions that define us.
This capacity of the adult brain to generate new neurons has been widely studied, in the perspective of its future application to regenerative therapies in the context of neurological and psychiatric diseases, such as Parkinson’s and Alzheimer’s Disease or Depression.
A team of researchers from the Life and Health Sciences Research Institute (ICVS) at the University of Minho (Braga, Portugal), leaded by Dr. Luisa Pinto and Professor Nuno Sousa, have identified a novel protein – AP2gamma – with an important role in the regulation of the production of new neurons in the adult brain.
“This protein was initially described to be altered in the pathogenesis of breast cancer by contributing to the proliferation of cancer cells. However, when we identified the presence of AP2gamma in the adult brain, we sought to understand its function in that context. For that, we genetically manipulated the expression of AP2gamma in mice and studied the molecular and behavioral outcomes of altering the levels of this protein” explained Dr. Pinto.
Results of the study shows that AP2gamma is essential for the generation of new neurons in the adult hippocampus and its absence compromises the performance in specific behavioral domains.
Image shows a drawing of the hippocampus.
Results of the study shows that AP2gamma is essential for the generation of new neurons in the adult hippocampus and its absence compromises the performance in specific behavioral domains. NeuroscienceNews.com image is for illustrative purposes only.
“Interestingly, the impairment of hippocampal neurogenesis, driven by the deletion of AP2gamma, leads to a dysfunctional communication between the hippocampus and the prefrontal cortex. In turn, this impaired communication between different regions of the brain seems to contribute to a deficient performance in cognitive tasks, such as in the consolidation of new memories or in spatial navigation” highlighted the co-authors of the study, Dr. Mateus-Pinheiro and Dr. Alves.
These observations contribute to a better understanding of the process of generation of new neurons in the adult brain and its impact in behavioral control. Next, Dr. Pinto’s team aims to understand the involvement of AP2gamma in stress-related disorders, such as Depression, where the production of new neurons has been shown to become compromised.
ABOUT THIS NEUROSCIENCE RESEARCH ARTICLE
NeuroscienceNews.com would like to thank Nuno Dinis Alves for submitting this research article to us for inclusion.
Source: Nuno Dinis Alves – University of Minho
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior” by A Mateus-Pinheiro, N D Alves, P Patrício, A R Machado-Santos, E Loureiro-Campos, J M Silva, V M Sardinha, J Reis, H Schorle, J F Oliveira, J Ninkovic, N Sousa and L Pinto in Molecular Psychiatry. Published online October 25 2016doi:10.1038/mp.2016.169
University of Minho “Protein Associated With Growth of Breast Cancer Essential for Production of New Neurons.” NeuroscienceNews. NeuroscienceNews, 28 October 2016.
.

Abstract
AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior
Hippocampal neurogenesis has been proposed to participate in a myriad of behavioral responses, both in basal states and in the context of neuropsychiatric disorders. Here, we identify activating protein 2γ (AP2γ, also known as Tcfap2c), originally described to regulate the generation of neurons in the developing cortex, as a modulator of adult hippocampal glutamatergic neurogenesis in mice. Specifically, AP2γ is present in a sub-population of hippocampal transient amplifying progenitors. There, it is found to act as a positive regulator of the cell fate determinants Tbr2 and NeuroD, promoting proliferation and differentiation of new glutamatergic granular neurons. Conditional ablation of AP2γ in the adult brain significantly reduced hippocampal neurogenesis and disrupted neural coherence between the ventral hippocampus and the medial prefrontal cortex. Furthermore, it resulted in the precipitation of multimodal cognitive deficits. This indicates that the sub-population of AP2γ-positive hippocampal progenitors may constitute an important cellular substrate for hippocampal-dependent cognitive functions. Concurrently, AP2γ deletion produced significant impairments in contextual memory and reversal learning. More so, in a water maze reference memory task a delay in the transition to cognitive strategies relying on hippocampal function integrity was observed. Interestingly, anxiety- and depressive-like behaviors were not significantly affected. Altogether, findings open new perspectives in understanding the role of specific sub-populations of newborn neurons in the (patho)physiology of neuropsychiatric disorders affecting hippocampal neuroplasticity and cognitive function in the adult brain.
“AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior” by A Mateus-Pinheiro, N D Alves, P Patrício, A R Machado-Santos, E Loureiro-Campos, J M Silva, V M Sardinha, J Reis, H Schorle, J F Oliveira, J Ninkovic, N Sousa and L Pinto in Molecular Psychiatry. Published online October 25 2016 doi:10.1038/mp.2016.169
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Internet Trends by vpnMentor

Internet Trends, stats & facts in the U.S. and Worldwide 2016

logo
The following collection of charts represents the most trusted research and the most recent data on major internet trends. Feel free to use the charts included here on your post on Internet World Usage Statistics, and do share it on social networks.
While dedicated to vpns and online privacy issues, vpnMentor also wants to be your resource for Internet trends and data.
As a result, we have scoured the most trusted researchers’ sites to present the following series of charts. Grouped by general topic, the information below represents the most recent data on major internet trends./.../

Thursday, October 27, 2016

Halloween

From Delanceyplace.com
In today's encore excerpt - the origins of Halloween:

"Halloween's origins date back to the ancient Celtic festival of Samhain (pronounced sow-in). The Celts, who lived 2,000 years ago in the area that is now Ireland, the United Kingdom and northern France, celebrated their new year on November 1. This day marked the end of summer and the harvest and the beginning of the dark, cold winter, a time of year that was often associated with human death. Celts believed that on the night before the new year, the boundary between the worlds of the living and the dead became blurred. On the night of October 31 they celebrated Samhain, when it was believed that the ghosts of the dead returned to earth. In addition to causing trouble and damaging crops, Celts thought that the presence of the otherworldly spirits made it easier for the Druids, or Celtic priests, to make predictions about the future. For a people entirely dependent on the volatile natural world, these prophecies were an important source of comfort and direction during the long, dark winter./.../