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Summary: Researchers suggest the ApoE gene could be a promising new target for therapeutic approaches for Alzheimer’s disease.
APOE gene is a promising target for therapeutic approaches to Alzheimer’s, says Tel Aviv University researcher.
For the last 20 years, researchers have focused on amyloid beta peptides and the “plaque” they sprout in diseased brains as the main target of Alzheimer’s research. But the pace of progress in treating — not to mention curing — the debilitating, neurodegenerative disease has been painfully slow.
A Tel Aviv University study published last month in the Journal of Alzheimer’s Disease suggests a new target for Alzheimer’s research: the APOE gene. This gene, like Dr. Jekyll and Mr. Hyde, has two faces: a healthy form called APOE3 and a disease-related pathological form called APOE4. Researchers have developed a novel mechanism and approach with which to convert the “bad” APOE4 to the “good” APOE3.
The research was led by Prof. Daniel M. Michaelson, Director of the Eichenbaum Laboratory of Alzheimer’s Disease Research and incumbent of the Myriam Lebach Chair in Molecular Neurodegeneration at TAU’s Faculty of Life Sciences, together with Anat Boehm-Cagan, the Eleanore and Harold Foonberg Doctoral Fellow in Alzheimers Disease Research, and in collaboration with the commercial company Artery Ltd., based in California./.../