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Summary: Researchers report mice can retain their memories and ability to learn when almost all ApoE is removed from the brain but kept present in the liver to filter cholesterol.
Source: UT Southwestern.
A protein linked to higher risk of Alzheimer’s can be removed from the brains of mice without hindering memory and learning, according to a study that addresses whether potential therapeutics targeting this protein would have detrimental side effects.
The study from the Peter O’Donnell Jr. Brain Institute also showed, however, that the protein’s absence in other parts of the body hinders brain function as blood cholesterol levels rise. This result substantiates previous research that indicated cardiovascular health affects the brain.
Researchers focused on the removal of apolipoprotein E (ApoE), which in a certain form can support the buildup of toxic plaques in the brains of Alzheimer’s patients. Studies elsewhere have sought to determine whether reducing ApoE could be an effective treatment in preventing the disease, but a lingering question has been whether the protein is necessary for healthy brain function./.../