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Gut Microbiota and Glucometabolic Alterations in Response to Recurrent Partial Sleep Deprivation in Normal-weight Young Individuals
Changes to the microbial community in the human gut have been proposed to promote metabolic disturbances that also occur after short periods of sleep loss (including insulin resistance). However, whether sleep loss affects the gut microbiota remains unknown. Methods
In a randomized within-subject crossover study utilizing a standardized in-lab protocol (with fixed meal times and exercise schedules), we studied nine normal-weight men at two occasions: after two nights of partial sleep deprivation (PSD; sleep opportunity 02:45-07:00h), and after two nights of normal sleep (NS; sleep opportunity 22:30-07:00h). Fecal samples were collected within 24 hours before, and after two in-lab nights, of either NS or PSD. In addition, participants underwent an oral glucose tolerance test following each sleep intervention.
Microbiota composition analysis (V4 16S rRNA gene sequencing) revealed that after two days of PSD vs. after two days of NS, individuals exhibited an increased Firmicutes:Bacteroidetes ratio and of the families Coriobacteriaceae and Erysipelotrichaceae, with decreases in Tenericutes (all P<0 .05="" acid="" after="" all="" and="" animal="" associated="" beta="" br="" concentrations="" decreased="" diversity="" effect="" fasting="" fatty="" fecal="" found.="" however="" human="" in="" insulin="" metabolic="" models.="" no="" ns="" on="" or="" p="" perturbations="" postprandial="" previously="" psd="" sensitivity="" short-chain="" style="box-sizing: border-box;" vs.="" was="" with="">0>
Our findings demonstrate that short-term sleep loss induces subtle effects on human microbiota. To what extent changes to the microbial community contribute to metabolic consequences of sleep loss warrants further investigations in larger and more prolonged sleep studies, to also assess how sleep loss impacts the microbiota in individuals who already are metabolically compromised.
“Gut Microbiota and Glucometabolic Alterations in Response to Recurrent Partial Sleep Deprivation in Normal-weight Young Individuals” by Christian Benedict, Heike Vogel, Wenke Jonas, Anni Woting, Michael Blaut, Annette Schürmann, and Jonathan Cedernaes in Molecular Metabolism. Published online October 24 2016 doi:10.1016/j.molmet.2016.10.003