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Saturday, October 31, 2015

Novembro Azul: Campanha

Preencha os campos abaixo para
baixar o KIT com as peças da Campanha
Novembro Azul


What Trick-or-Treating Tells Us About Human Nature
The annual Halloween tradition of using kids as research subjects has recently seen renewed interest; the appeal is that these real-life examples can offer insights into human behavior

End-of-Life Dementia

End-of-Life Dementia Costs More Than Heart D,.Cancer

Pauline Anderson
October 30, 2015
The study, which investigated social costs and financial risks faced by Medicare beneficiaries during the 5 years before death, found that healthcare spending for dementia topped $250,000 per person, about 57% more than costs associated with death from other diseases, including cancer and heart disease.
The new analysis, carried out by Amy S. Kelley, MD, Icahn School of Medicine at Mount Sinai, New York, New York, and colleagues, was published online October 27 in the Annals of Internal Medicine.
"This complex analysis lays out the significant health care costs to society and individuals" at the end of life, said Richard J. Hodes, MD, director, National Institute on Aging (NIA), which funded the analysis, in a press release./.../

Telomere and AD

Megan Brooks

October 30, 2015 Shortening a Cause of Alzheimer's Disease?

A new study provides evidence for the first time of a causal relationship between telomere length (TL) and Alzheimer's disease (AD), say investigators from Sweden.
"This is the first study addressing the causal effect of TL on AD," principal investigator Sara Hägg, PhD, docent of molecular epidemiology, Karolinska Institutet, Stockholm, toldMedscape Medical News.
Telomeres are repetitive DNA sequences at the ends of chromosomes that progressively shorten with age. Observational studies suggest that shorter telomeres are associated with shorter life expectancy and greater risk for age-related diseases, including AD. However, these studies could have residual confounding or reverse causation, making it difficult to draw conclusions on whether TL is causally associated with AD./.../


Long-term aerobic exercise prevents age-related brain deterioration
October 30, 2015

age-related changes ftA study of the brains of mice shows that structural deterioration associated with old age can be prevented by long-term aerobic exercise starting in mid-life, according to the authors of an open-access paper in the journal PLOS Biology yesterday (October 29). Old age is the major risk factor for Alzheimer’s disease, like many other diseases, as … more…

A drug-delivery technique to bypass the blood-brain barrier
October 26, 2015

Could benefit a large population of patients with neurodegenerative disorders
Researchers at Massachusetts Eye and Ear/Harvard Medical School and Boston University have developed a new technique to deliver drugs across the blood-brain barrier and have successfully tested it in a Parkinson’s mouse model (a line of mice that has been genetically modified to express the symptoms and pathological features of Parkinson’s to various extents). Their findings, … more…
What happens in the brain when we learn
October 28, 2015

These are isolated cells in the visual cortex of a mouse (credit: Alfredo/Kirkwood (JHU)) 
Findings could enhance teaching methods and lead to treatments for cognitive problems
A Johns Hopkins University-led research team has proven a working theory that explains what happens in the brain when we learn, as described in the current issue of the journal Neuron. More than a century ago, Pavlov figured out that dogs fed after hearing a bell eventually began to salivate when they heard the bell ring. … more…

Sleep disruptions similar to jet lag linked to memory and learning problems
October 29, 2015

(credit: iStock)
Add good sleep habits to regular exercise and a healthy diet to maximize good memory, scientists advise
Chemical changes in brain cells caused by disturbances in the body’s day-night cycle may lead to the learning and memory loss associated with Alzheimer’s disease, according to a University of California, Irvine (UCI) study. People with Alzheimer’s often have problems with sleeping or may experience changes in their slumber schedule. Scientists do not completely understand … more…

Friday, October 30, 2015

Onde andam as Sulfas?!...

Domagk, Gerhard [Credit: Archiv für Kunst und Geschichte, Berlin]
Gerhard Domagk,  (born Oct. 30, 1895, Lagow, Brandenburg, Ger.—died April 24, 1964, Burgberg, near Königsfeld, W.Ger.), German bacteriologist and pathologist who was awarded the 1939 Nobel Prize forPhysiology or Medicine for his discovery (announced in 1932) of the antibacterial effects of Prontosil, the first of the sulfonamide drugs.
Domagk earned a medical degree from the University of Kiel in 1921. After teaching at the universities of Greifswald (1924) and Munich (1925), he became director of the I.G. Farbenindustrie (Bayer) Laboratory for Experimental Pathology and Bacteriology, Wuppertal-Elberfeld. There, inspired by the ideas of Paul Ehrlich, he began testing newly developed dyes ... (100 of 203 words)

Thursday, October 29, 2015

Lifelong memory

Emily Underwood
Studies suggest key role for perineuronal networks of proteins and sugars in long-term memory.


Fim do Estado Novo. Renúncia de Getúlio Vargas

Ageing Cities

24 Sep 2015

Arup has launched “Shaping Ageing Cities” – a new report that analyses how ten European cities are responding to ageing. Cover of the report. Credit: Arup.

We are living in the urban and ageing era. In 2050, for the first time in human history, the number of older people will be greater than the number of children under 15 years old. As cities across the globe continue to grow, more people are growing old in housing, streets, communities that often are failing to respond appropriately to ageing populations with specific policies.
How can cities respond to this demographic change and deliver appropriate solutions? This forward-thinking report, undertaken by Arup in collaboration with HelpAge InternationalIntel ICRI Cities and Systematicaaddresses this global concern through a comparative overview of the performance of 10 European cities.
The report analyses these key issues according to ageing data and observing them under the lenses of society, mobility, built and digital environment and sets up the basis to further investigate the correlation among politics, planning and ageing.
"Cities and urban environments have a fundamental role in defining how to deal with our ageing society. This provides a unique opportunity to influence and design urban environments and social structures in ways that respect, protect and fulfil our rights, including in our older age."
—Stefano Recalcati, Associate, Milan
Shaping Ageing Cities defines a methodology to study ageing in European cities; understanding main features such as transportation, income, outdoor spaces, building design, social inclusion, ICT and health services in order to apply this experience to the growing market related to city-making.

Wednesday, October 28, 2015

microbiota e aterosclerose

Academia Global de Aterosclerose
Função da microbiota na aterosclerose
A microbiota intestinal pode ser um potencial alvo terapêutico no controle de doenças metabólicas

Botox na FA

Botox pode evitar fibrilação atrial após cirurgia de revascularização 
Injeções nos coxins de gordura em volta do coração reduzem de modo considerável incidências de fibrilação atrial.

Cidadania no Século XXI

Fernando Savater (link para dados sobre o conferencista)

A educação do cidadão no século XXI (resumo)

Primeira página jornais

 Enviado por meu primo Nilo Sérgio Cechella

Stephen Leeder

Enviado pela AMICOR Maria Inês Reinert Azambuja

Australian academics seek to challenge 'web of avarice' in scientific publishing

In the wake of editor-in-chief Stephen Leeder’s sacking from the Medical Journal of Australia, academics are challenging the control of a select group of publishing houses over scientific journals
Mitchell Library Reading Room at the State Library of New South Wales
Leeder told Guardian Australia he still felt “pretty beaten up” by the MJA experience, knowledge and scholarly information had gone from being a public good to a “commercial, tradable commodity”.
“The whole academic publishing industry is a gigantic web of avarice and selfishness, and the academic community has not engaged to the extent it perhaps should have to stop it,” Leeder said.
“Scholarly publishing is a bit like the Trans-Pacific Partnership Agreement. It’s not totally clear what the hell is going on, but you can be sure someone is making a hell of a lot of money from it.”/.../

Tuesday, October 27, 2015


Rise of the Microglia

New research shows that the resident immune cells of the brain are involved in both development and disease

Microglia, the immune cells of the brain, have long been the underdogs of the glia world, passed over for other, flashier cousins, such as astrocytes. Although microglia are best known for being the brain’s primary defenders, scientists now realize that they play a role in the developing brain and may also be implicated in developmental and neurodegenerative disorders. The change in attitude is clear, as evidenced by the buzz around this topic at this year’s Society for Neuroscience (SfN) conference, which took place from October 17 to 21 in Chicago, where scientists discussed their role in both health and disease.
Activated in the diseased brain, microglia find injured neurons and strip away the synapses, the connections between them. These cells make up around 10 percent of all the cells in the brain and appear during early development. For decades scientists focused on them as immune cells and thought that they were quiet and passive in the absence of an outside invader. That all changed in 2005, when experimenters found that microglia were actually the fastest-moving structures in a healthy adult brain. Later discoveries revealed that their branches were reaching out to surrounding neurons and contacting synapses. These findings suggested that these cellular scavengers were involved in functions beyond disease.
The Brain’s Sculptors 
The discovery that microglia were active in the healthy brain jump-started the exploration into their underlying mechanisms: Why do these cells hang around synapses? And what are they doing?/.../

Sunday, October 25, 2015

Maranhão em Shanghai

Visita ao Prof. GE Junbo, Presidente da Sociedade Chinesa de Cardiologia, em Shanghai como Prof. Visitante no 10th Hospital da Tongji University por 1 mês.

2729 - AMICOR 18


Aloyzio AchuttiemAMICOR - Há 2 horas
Ask Ray | Health technologies to support sleep apnea and snoringJune 22, 2015 [image: credit | Airing] Dear readers, Obstructive sleep apnea is a very common sleep disorder caused by periodic obstruction of the upper airway. A sleep apnea is literally a pause in breathing. It can happen many times each hour while the individual is asleep. It leads to reduced oxygen saturation and is a risk factor for heart disease. Most sufferers are unaware that they have this syndrome. It is often first noticed… read more


Aloyzio AchuttiemAMICOR - Há 2 horas
Mass extinctions linked to comet and asteroid showers October 22, 2015 [image: Mass extinctions occurring over the past 260 million years were likely caused by comet and asteroid showers, a new study concludes. An artist's illustration of a major asteroid impact on Earth. (credit: NASA/Don Davis)]Mass extinctions occurring over the past 260 million years were likely caused by comet and asteroid showers, scientists conclude in a new study published in an open-access paper in Monthly Notices of the Royal Astronomical Society. For more than 30 years, scientists have argued about a cont... mais »


Aloyzio AchuttiemAMICOR - Há 2 horas
Improving learning and memory in aged mice with cholesterol-binding membrane protein October 22, 2015 [image: SynCav1 gene delivery enhances granule cell neuron dendritic arborization (neuron branching in adult mice. Scale bar: 20 micrometers (credit: Chitra D. Mandyam et al./Biological Psychiatry)] Using gene therapy to increase a crucial cholesterol-binding membrane protein called caveolin-1 (Cav-1) in neurons in the hippocampus* of the brain improved learning and memory in aged mice, according to findings from a new study led by scientists at The Scripps Research Institute (TSRI),... mais »

Camillo Golgi (1843-1926)

Aloyzio AchuttiemAMICOR - Há 2 horas
The First Neuron Drawings, 1870s Camillo Golgi’s black reaction revealed, for the first time, the fine structures of intact neurons, which he captured with ink and paper. By Amanda B. Keener | October 1, 2015 A FIRST LOOK: Camillo Golgi’s original black-and-white drawing of a dog’s olfactory bulb appeared in a paper in the *Rivista Sperimentale di Freniatria e Medicina Legale*in 1875. Colored plates appeared in reprinted versions distributed by Golgi and in the German translation of his paper. Golgi indicated three layers in his drawing. The superficial layer (A) is composed of nerve... mais »

AD and Thyroid

Aloyzio AchuttiemAMICOR - Há 2 horas
High Thyroid Function Linked to Dementia Nancy A Melville October 23, 2015t EDITORS' RECOMMENDATIONS - One Target, One Treatment? Not for Alzheimer's Disease - A Saliva Test for Alzheimer's Disease? RELATED DRUGS & DISEASES - Thyroid Dysfunction Induced by Amiodarone Therapy - Autoimmune Thyroid Disease and Pregnancy - Alzheimer Disease "This finding provides more insight into the possible importance of other pathways connecting thyroid function to dementia and could provide new targets for therapeutic agents," she said. In terms of the gender differences, the research... mais »

Prions e Idions

Aloyzio AchuttiemAMICOR - Há 2 horas

Diet and Brain

Aloyzio AchuttiemAMICOR - Há um dia
Mediterranean Diet Linked to Larger Brain Volume Megan Brooks October 22, 2015 EDITORS' RECOMMENDATIONS - Mediterranean Diet May Preserve Brain Structural Connectivity - Med Diet With Nuts, Olive Oil Linked to Better Cognition - 'Common Sense' Lifestyle Factors May Delay Dementia Onset A new study provides more evidence that following a Mediterranean-type diet (MeDi) is good for the brain. In a multiethnic cohort of elderly dementia-free adults, those more adherent to the MeDi had larger brain volume than their less adherent peers. And the difference between the groups is equ... mais »


Aloyzio AchuttiemAMICOR EXTENSION - Há um dia
*PROPÓSITO II* [image: Imagem para o resultado de notícias]Este é um retorno ao propósito inicial que como pode ser visto na primeira postagem AMICOREXTENSION (outubro 2012) do que pretendia ser uma extensão do Blog AMICOR. Como escrevi naquela ocasião - o que pode ser visitado na página *PROPÓSITO - *a intensão era de elaborar uma coletânea de artigos e, em releitura, comentar, acrescentar ou corrigir, e eventualmente publicar em livro ou em forma de e-book. [image: Resultado de imagem para adib jatene]Passados três anos estou tentando retomar o projeto, justamente hoje que um d...mais »

NEJM 200 years athand

Aloyzio AchuttiemAMICOR EXTENSION - Há um dia FEATURED MULTIMEDIA - [image: 200 Years of NEJM] 200 Years of NEJM D.C. Müller, E.M.C. Duff, and K.L. Stern - Interactive Timeline -

Internet Delusion

Aloyzio AchuttiemAMICOR - Há um dia
- [image: (Credit: Getty Images)] - Neurohacks Is Google making us know-it-alls? - The internet can give us the illusion of knowledge, making us think we are smarter than we really are. Fortunately, there may be a cure for our arrogance, writes psychologist Tom Stafford. -

Fernando Savater

Aloyzio AchuttiemAMICOR - Há 2 dias
*Fronteiras do Pensamento dia 26/10/2015*


Aloyzio AchuttiemAMICOR - Há 2 dias
People with Parkinson’s walk again after promising drug trial A cancer drug may be the first treatment to reverse Parkinson's disease, and has allowed bedridden people in a small trial to walk again [image: People with Parkinson's walk again after promising drug trial] IT IS the first drug that seems to directly target the causes of Parkinson’s disease. People taking part in a safety trial have had their symptoms reversed, allowing them to talk, get out of bed and feed themselves once again. Although there are already several treatments for the symptoms of Parkinson’s, this could be th... mais »

James Lind Library

Aloyzio AchuttiemAMICOR - Há 3 dias
*Indicado pela AMICOR Maria Inês Reinert Azambuja*Using the Library This page tells you briefly what’s in the James Lind Library, how it’s organised and how to search it. For more detailed information about how we built the Library, please see Building the Library. If you prefer to be shown than told, watch the short videos. Introduction to the James Lind Library The Library contains material illustrating the development of fair tests of treatments throughout history. How is the James Lind Library organised? The material in the Library is organised under methodological Topics, each of w... mais »

James Lind (1716-1794)

Aloyzio AchuttiemAMICOR - Há 3 dias
James Lind[image: A portrait of Scottish doctor James Lind (1716–1794)]Born4 October 1716 EdinburghDied13 July 1794 (aged 77) Gosport, HampshireEducationHigh School, Edinburgh Edinburgh University (MD 1748) Royal College of Physicians of Edinburgh (LRCPE)Known forprevention of maritime diseases and cure for scurvy*Medical career*Professionmilitary surgeonInstitutionsSurgeon, Royal Navy (1739–48) Physician, Edinburgh (1748–58) Senior Physician, Haslar Naval Hospital (1758–83)Specialismnaval hygiene


Aloyzio AchuttiemAMICOR - Há 3 dias
Função dos microRNAs na aterosclerose - EAS Snapshots - 19/10/2015 - 1 Visualizações - - Sem avaliação [image: Os miRNAs têm potencial como biomarcadores e alvos terapêuticos na aterosclerose e doença cardiovascular] MicroRNAs (miRNAs) são pequenas moléculas de RNA (22 nucleotídeos) não codificadoras que surgiram como reguladores essenciais da expressão gênica em nível pós-transcricional. Os miRNAs normalmente controlam a expressão de seus genes-alvo pelo pareamento imperfeito de bases com as regiões 3’ não traduzidas de RNAs mensageiros (mRNAs), induzi... mais »


Aloyzio AchuttiemAMICOR - Há 3 dias
Origem da esquizofrenia pode estar em oligodendrócitos - DOC Content - 19/10/2015 - 1 Visualizações - - Sem avaliação [image: Estudo busca entender o que ocorre nos oligodendrócitos de pacientes com esquizofrenia] Pesquisadores publicam estudos apresentando novo olhar sobre a origem da esquizofrenia Células cerebrais importantes na atividade dos neurônios, os oligodendrócitos, quando com disfunções, podem ter papel fundamental no desenvolvimento da esquizofrenia. Essa é a abordagem de estudos feitos no Instituto de Biologia da Universidade Estadual de Cam... mais »

RAS and relationship with Alzheimer Disease

Aloyzio AchuttiemAMICOR - Há 4 dias
Modulation of Renin-angiotensin System May Slow Conversion From Mild Cognitive Impairment to Alzheimer's Disease Whitney Wharton, PhD; Felicia C. Goldstein, PhD; Liping Zhao, MSPH; Kyle Steenland, PhD; Allan I. Levey, MD, PhD; Ihab Hajjar, MD, MS Disclosures J Am Geriatr Soc. 2015;63(9):1749-1756. - Abstract and Introduction - Abstract *Objectives:* To assess the effect of modulation of the renin-angiotensin system (RAS) on conversion to Alzheimer's disease (AD) and cognitive decline in people with mild cognitive impairment (MCI) and the effect of the permeability of ...mais »


Aloyzio AchuttiemAMICOR - Há 4 dias
How Einstein Revealed the Universe's Strange "Nonlocality" Our sense of the universe as an orderly expanse where events happen in absolute locations is an illusion By George Musser | Oct 20, 2015 *Edward Kinsella III* In Brief - In everyday life, distance and location are mundane absolutes. Yet physics now suggests that at the most fundamental level, the universe is nonlocal—there is no such thing as place or distance. - Initially Isaac Newton's conception of gravity seemed to imply the phenomenon of nonlocality because the attractive force between masses appear... mais »

Nossas Metrópoles

Aloyzio AchuttiemAMICOR - Há 5 dias
*Referência da AMICOR Maria Inês Reinert Azambuja*Novo post em *blog da Raquel Rolnik*Como andam nossas metrópoles?by raquelrolnik O Ipea acaba de divulgar o Atlas da Vulnerabilidade Social nas Regiões Metropolitanas, uma cartografia da vulnerabilidade social e de sua evolução entre 2000 e 2010, para as regiões metropolitanas do Rio de Janeiro, Vitória, São Paulo, Belo Horizonte, Curitiba, Porto Alegre, Cuiabá, Distrito Federal, Belém, Fortaleza, Goiânia, Manaus, São Luiz, Natal, Salvador e Recife. A pesquisa utiliza o Índice da Vulnerabilidade Social (IVS), calculado a partir da méd... mais »

Queimando-nos a nos mesmos...

Aloyzio AchuttiemAMICOR - Há 5 dias
*Referência enviada pelo próprio Dr. Aristóteles - AMICOR entrevistado* Fumaça das queimadas são um verdadeiro risco à saúde O cardiologista Aristóteles Alencar explica que a poluição causada pelas queimadas é um perigo para o manauense Manaus (AM), 18 de Outubro de 2015 ISABELLE VALOIS [image: Conforme Alencar, fumaça de queimadas tem poluentes químicos que podem chegar ao sangue e causar graves problemas] Conforme Alencar, fumaça de queimadas tem poluentes químicos que podem chegar ao sangue e causar graves problemas (Márcio Silva)