Translate AMICOR contents if you like

Saturday, October 03, 2015

Virus are alive

Study of protein folds adds to evidence that viruses are alive and ancient

Scientists estimate there are more than a million viral species, but less than 4,900 viruses have been identified and sequenced
October 1, 2015
[+]
The diverse physical attributes, genome sizes and lifestyles of viruses make them difficult to classify. A new study uses protein folds as evidence that viruses are living entities that belong on their own branch of the tree of life. (credit: Julie McMahon)
Viruses are actually living entities that share a long evolutionary history with cells, researchers report in a study that traces viral evolution back to a time when neither viruses nor cells existed in the forms recognized today.
The new findings appear in an open-access paper in the journal Science Advances.
Abstract of A phylogenomic data-driven exploration of viral origins and evolution
The origin of viruses remains mysterious because of their diverse and patchy molecular and functional makeup. Although numerous hypotheses have attempted to explain viral origins, none is backed by substantive data. We take full advantage of the wealth of available protein structural and functional data to explore the evolution of the proteomic makeup of thousands of cells and viruses. Despite the extremely reduced nature of viral proteomes, we established an ancient origin of the “viral supergroup” and the existence of widespread episodes of horizontal transfer of genetic information. Viruses harboring different replicon types and infecting distantly related hosts shared many metabolic and informational protein structural domains of ancient origin that were also widespread in cellular proteomes. Phylogenomic analysis uncovered a universal tree of life and revealed that modern viruses reduced from multiple ancient cells that harbored segmented RNA genomes and coexisted with the ancestors of modern cells. The model for the origin and evolution of viruses and cells is backed by strong genomic and structural evidence and can be reconciled with existing models of viral evolution if one considers viruses to have originated from ancient cells and not from modern counterparts.

No comments: