Megan BrooksOctober 30, 2015 Shortening a Cause of Alzheimer's Disease?
A new study provides evidence for the first time of a causal relationship between telomere length (TL) and Alzheimer's disease (AD), say investigators from Sweden.
"This is the first study addressing the causal effect of TL on AD," principal investigator Sara Hägg, PhD, docent of molecular epidemiology, Karolinska Institutet, Stockholm, toldMedscape Medical News.
Telomeres are repetitive DNA sequences at the ends of chromosomes that progressively shorten with age. Observational studies suggest that shorter telomeres are associated with shorter life expectancy and greater risk for age-related diseases, including AD. However, these studies could have residual confounding or reverse causation, making it difficult to draw conclusions on whether TL is causally associated with AD./.../