January 15, 2020
Hongwei Ji, MD1,2,3; Andy Kim, BA1,2,4; Joseph E. Ebinger, MD5; et alTeemu J. Niiranen, MD6,7; Brian L. Claggett, PhD1; C. Noel Bairey Merz, MD4; Susan Cheng, MD, MPH, MMSc1,2,4
JAMA Cardiol. 2020;5(3):19-26. doi:10.1001/jamacardio.2019.5306
Key Points
Question How do patterns of blood pressure (BP) change over the life course and differ between sexes?
Findings In this analysis of 4 community cohort studies, trajectories of BP elevation in 32 833 individuals (54% women) were examined serially over 4 decades (age span, 5 to 98 years). Women compared with men exhibited a steeper increase in BP measures that began as early as in the third decade and continued throughout the life course.
Meaning Sex differences in BP trajectories, which begin early and persist with aging, may set the stage for later-life cardiovascular diseases that frequently present differently in women vs men.
Abstract
Importance If we assume that women and men exhibit variations of the same fundamental vascular physiology, then conventional analyses of subclinical measures would suggest that women catch up to men by midlife in the extent of potentially important vascular disease. Alternatively, under the assumption that vascular physiology may fundamentally differ between women and men, a sex-specific analysis of existing data could offer new insights and augment our understanding of sex differences in cardiovascular diseases.
Objective To evaluate whether longitudinal patterns of blood pressure (BP) elevation differ between women and men during the life course when considering baseline BP levels as the reference.
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