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Friday, July 31, 2020

preventing 40% of dementia cases

Artigo do  The Guardian, recomendado pelo nosso neto  Antônio A. Olivé
Lifestyle changes could delay or prevent 40% of dementia cases – study Addressing 12 factors such as excessive drinking and air pollution exposure may have significant effect, experts say The hands of an elderly woman Around 50 million people around the world live with dementia, including about 850,000 people in the UK. Photograph: Yui Mok/PA Nicola Davis @NicolaKSDavis Published onThu 30 Jul 2020 17.30 BST 1,040 Excessive drinking, exposure to air pollution and head injuries all increase dementia risk, experts say in a report revealing that up to 40% of dementia cases worldwide could be delayed or prevented by addressing 12 such lifestyle factors. Around 50 million people around the world live with dementia, including about 850,000 people in the UK. By 2040, it has been estimated there will be more than 1.2 million people living with dementia in England and Wales. There is currently no cure. However, while some risk factors for dementia cannot be changed, for example particular genes or ethnicity, many are down to lifestyle. “Dementia is potentially preventable – you can do things to reduce your risk of dementia, whatever stage of life you are at,” said Gill Livingston, professor of psychiatry of older people at University College London and a co-author of the report. She added such lifestyle changes could reduce the chances of developing dementia in both those with and without a high genetic risk for such conditions. The report from the Lancet Commission on dementia prevention, intervention and care builds on previous work revealing that about a third of dementia cases could be prevented by addressing nine lifestyle factors, including midlife hearing loss, depression, less childhood education and smoking. Lifestyle changes could prevent a third of dementia cases, report suggests Read more The research weighs up the latest evidence, largely from high-income countries, supporting the addition of a further three risk factors to the list. It suggests that 1% of dementia cases worldwide are attributable to excessive mid-life alcohol intake, 3% to mid-life head injuries and 2% a result of exposure to air pollution in older age – although they caution that the latter could be an underestimate. Advertisement While some actions can be taken on a personal level to tackle such issues, many require government-led change, Livingston said. The report includes a list of nine recommendations, including improving air quality, and urges policymakers to “be ambitious about prevention”. Artigo recomendado por nosso neto Antônio A. Olivé Livingston praised Boris Johnson’s campaign to tackle the nation’s waistlines and reduce Covid-19 deaths, as obesity and lack of exercise are among the risk factors for dementia. “That may be helpful, particularly if they are beginning to think about obesogenic environments and making it safe for people to ride bikes,” she said. While Livingston said the 40% figure was optimistic as the 12 risk factors are unlikely to be completely addressed, small steps could make a difference. Research has suggested that the incidence of dementia in Europe and North America has fallen by around 15% per decade for the past 30 years – likely because of lifestyle changes such as a reduction in smoking – even though the numbers of people with dementia are rising as people live longer. The impact of lifestyle interventions, the team add, is likely to be greatest among the most deprived individuals and in low- and middle-income countries. “I don’t think it is any coincidence that the reductions in dementia prevalence to date have been in high-income, highly educated people who have more control over their environment,” said Livingston. “We are expecting by 2050 that two-thirds of people with dementia, if trajectories continue, will be in low-income countries.” It is not clear whether all the risk factors are purely a cause rather than an effect of dementia. The report notes: “Depression might be a risk for dementia, but in later life dementia might cause depression.” Fiona Carragher, director of research and influencing at Alzheimer’s Society, which part-funded the work, called for a boost to dementia research, warning that medical research charities are facing a 40% average fall in research funding because of the Covid-19 pandemic. Fiona Matthews, professor of epidemiology at Newcastle University, who was not involved in the report, said the focus on lifestyle did not mean people should feel they are to blame if they develop dementia. “We can work at reducing our personal risk and society’s risk, but still even then with these risk factors it only equates to less than 50% of all dementia,” she said, adding that an increase in risk did not mean dementia was certain to develop. Matthews said tackling lifestyle risk factors, personally and as a society, remained important, adding that inequalities in population health, as highlighted by Covid-19, should be targeted. “The crucial component is that in the absence of treatments that delay or postpone dementia, reducing everyone’s risk is the best method to slow the increasing numbers of people with dementia that we would see due to population ageing,” she said. you.

Our cosmic horizon; introverts in an extraverts’ world; and a utopian reboot of money This week in Friday 31 July 2020

Our cosmic horizon; introverts in an extraverts’ world; and a utopian reboot of money Caixa de entrada x Aeon Magazine Cancelar inscrição 13:40 (há 2 horas) para mim This week in Friday 31 July 2020

3,000-year-old head may be face of God

This head excavated recently by archaeologists at the site of Khirbet Qeiyafa in Israel may depict Yahweh.
The head dates back almost 3,000 years and was found in a large building that may have been a palace.
(Image: © Clara Amit/Israel Antiquities Authority)

A clay head that dates back almost 3,000 years may be a rare depiction of Yahweh, — God — whose image the Israelites were forbidden from creating according to the Ten Commandments, an archaeologist reports.

But two experts in the field have denounced the idea that this head figure represents God.

Yahweh is the God of Israel; however, according to the Hebrew Bible, the ancient Israelis were forbidden from creating depictions of Yahweh, as one of the 10 commandments stated that "you shall not make for yourself an image in the form of anything in heaven above or on the earth beneath or in the waters/.../

Thursday, July 30, 2020

Sleeping microbes

Sleeping microbes wake up after 100 million years buried under the seafloor

A magnified image shows the revived microbes.
A magnified image shows the revived microbes.
(Image: © JAMSTEC)

Microbes found themselves buried in the dirt 101.5 million years ago, back before even Tyrannosaurus rex when Earth’s biggest meat-eating dinosaur, called Spinosaurus roamed the planet. Time passed, continents shifted, oceans rose and fell, great apes emerged, and eventually human beings evolved with the curiosity and skills to dig up those ancient cells. And now, in a Japanese lab, researchers have brought the single-celled organisms back to life.

Researchers aboard the drill ship JOIDES Resolution collected sediment samples from the bottom of the ocean 10 years ago. The samples came from 328 feet (100 meters) below the 20,000-foot-deep (6,000 m) bottom of the South Pacific Gyre. That's a region of the Pacific Ocean with very few nutrients and little oxygen available for life to survive on, and the researchers were looking for data on how microbes get along in such a remote part of the world.


Otto von Bismarck +30/07/1898

Em 1898 foi fundada a Faculdade de Medicina de Porto Alegre, RS. Também nasceu meu pai Bortholo Achutti
Otto von Bismarck
Death of Otto von Bismarck (from E. Britannica)
Otto von Bismarck—who, as prime minister of Prussia (1862–73, 1873–90), used ruthlessness and moderation to unify Germany, founding the German Empire (1871) and serving as its first chancellor (1871–90)—died this day in 1898.

Sir Frederick G. Banting and Charles H. Best.

Charles H. Best and Frederick Banting with one of the first dogs that received insulin during their research.
Insulin was first isolated as a pancreatic extract by the Canadian scientists Sir Frederick G. Banting and Charles H. Best.

Wednesday, July 29, 2020

Depressão e Sistema imunitário

Ayuhasca e resposta na depressão e imunidade
Publicação da Folha de São Paulo recomendada pela AMICOR Maria Inês Reinert Azambuja

Alzheimer Disease


Flu, pneumonia vaccines linked to reduced risk of Alzheimer's
International investigators, clinicians and care researchers gathered virtually this week for the Alzheimer's Association International Conference® 2020 (AAIC®) to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science. Studies presented at AAIC suggest flu and pneumonia vaccinations — especially multiple vaccinations over time — are associated with a lower risk of Alzheimer's in later life.

Click here to read more
Studies show blood tests for Alzheimer's might be on the horizon
Multiple studies reported at AAIC showed advances in blood tests for abnormal versions of the Alzheimer's-related protein tau. A blood test has the potential to make diagnosis simpler, more affordable and widely available.
Click here to read more

New study announced to understand impact of COVID-19 on the brain
The COVID-19 pandemic continues to create additional challenges for people living with Alzheimer's and all dementia, their families and caregivers. At AAIC, the Alzheimer's Association announced a new research study to globally track and understand the long-term impact of the novel coronavirus on the brain.
Click here to read more

Miocardite por COVID 19

Recomendado pela AMICOR Maria Inês Reinert Azambuja

Covid atinge o coração e inflamação em músculo é achada semanas após recuperação, apontam estudos | Coronavírus | G1



Tuesday, July 28, 2020

World War I (1914)

German infantrymen operating a machine gun during World War I.
FEATURED EVENT1914Beginning of World War I
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Monday, July 27, 2020

COVID-19 The Lancet

Do grupo sobre Saúde Urbana da UFRGS
Se alguém estava ainda ansioso com a volta do "normal", é preciso ler o editorial do Lancet: 

*Do you long for a return to normal after COVID-19?*
Before the pandemic, 734 million people lived in extreme poverty, 690 million people went hungry, and 79·5 million people were forcibly displaced. Bill Gates and the late great Hans Rosling would tell you that the world is in a better state than you might expect, and that huge progress has been made. They would be right. Yet for billions of people, normal—ie, life before COVID-19—was not working. We might not be able to return to normal, but perhaps we should not want to. With the climate crisis pressing in, we cannot afford to. COVID-19 is a human catastrophe, but it gives the health community an opportunity to rethink the purpose of society in a fractured world and to redefine what we want normal to mean.
The pandemic has two salutary lessons for societies. First, it has reminded us who truly keeps society functioning: key workers. Health workers and care workers, shop workers and social workers, bus drivers, teachers, bank tellers, police officers, farmers, and cleaners. Society often takes these workers for granted, but without them, we would sink into chaos.
The second is that society and its systems are much more fragile than many of us appreciated. Some of the very best health systems have so far averted total collapse only through extreme emergency measures and heroic personal efforts, with ventilator shortages, crises over personal protective equipment, oxygen stockouts, and the pressure on the health workforce. Food systems have proven flimsy when faced with stockpiling and disruptions to just-in-time supply chains. Job markets have evaporated in a matter of weeks. The decline of the high street and a hollowing-out of city centres are accelerating. Fragility is not some special property of war-torn countries; it is here, among us all.
While many countries face a worsening epidemic, there is talk of recovery and what form it should take. If we are to learn from these lessons, we must make equity, resilience, and sustainability the priorities for our future.
The pandemic is amplifying inequalities. The direct health effects of COVID-19 differ by race, gender, wealth, and comorbidity. Disruptions to wider health services, such as routine vaccination and the prevention and treatment of non-communicable diseases, are likely to worsen existing health inequities. The effects on social determinants of health are devastating too. School and university education has stalled. Businesses have closed and 1·6 billion workers in the informal economy, many with no other means of support, are affected by COVID-19 restrictions. At least 70 million more people will be pushed into poverty because of the pandemic. John Alston, the outgoing UN Special Rapporteur on Extreme Poverty and Human Rights, argues that extreme poverty has been neglected and that we need to reconceive the relationship between growth and poverty elimination. Decreasing the Gini coefficient, a measure of equality, in each country by 1% per year could have a bigger impact on global poverty than increasing annual growth by 1 percentage point. Wealth redistribution, not growth alone, is essential.
To address the fragility in our systems, we need resilience: an ability to cope with stresses, shocks, and change. A resilient health system has effective responses to health emergencies. It has surge capacity. It has a commitment to quality improvement. It is flexible and can adapt. A resilient health system would not plan for an influenza pandemic and then follow that plan when a coronavirus outbreak occurs. Economic systems need to be resilient too. The focus of orthodox economics on efficiency needs to be reconsidered. Pandemics, climate disasters, and financial meltdowns might feel exceptional, but they are not unexpected. We ought to recalibrate our priorities towards resilience to have a chance of coping with them.
We need to focus on sustainability for health, society, and the planet. The idea of a Green New Deal, which links the climate agenda to economic justice and redistribution, and a green and healthy recovery from the pandemic, have been gaining political support, at least in rhetoric, but they will only scratch the surface of what is needed. The opportunity to sharply accelerate climate policy must be embraced.
The need to challenge society's normal obsessions—efficiency, consumption, and growth—is not a new idea, even to economists. But the health community has a renewed moral authority to call for this challenge. This will require a change of culture as well as a change of metrics. The individuals, institutions, organisations, and societies that have these obsessions at heart need to think again. *Normal will no longer do*.

Franklin Veríssimo (* 27/07/1920 )

ACADEMIA SUL-RIOGRANDENSE DE MEDICINA está de parabéns. Hoje celebra o Centenário de mais um Acadêmico Fundador

Da biografia do Fundador da Cadeira 29 (Patrono João Lisboa de Azevedo),  por sua viúva a exma escritora Vera Elisabeth Veríssimo
Franklin Verissimo nasceu em 27 de julho de 1920, em Cruz Alta/RS, e faleceu em 06 de setembro de 1990, em Porto Alegre. Era filho de Fabricio Verissimo, odontólogo e Daura Galvão Verissimo, do lar. Do ramo Verissimo ligado ao campo e à medicina, herdou o nome do vô Franklin, médico prático, a dedicação à profissão, com altruísmo e independência. Do ramo Galvão, um avô engenheiro, Ramiz Galvão, ligado à VFRGS, o espírito de construir e de rupo. De sua vivência familiar, da formação básica em colégios da cidade até concluir o
Ginásio, e da amizade com a família Miranda e Westphalen, também de médicos e atuantes na ocalidade, trouxe para Porto Alegre sua cultura gaúcha de firmeza de ideias e busca de conhecimento. Aqui fez o curso preparatório para a Universidade e devido à classificação de vestibular da época fez o 1º ano do curso de Medicina no Rio de Janeiro, porém, ligado ao RS, voltou no 2º ano para Porto Alegre para seguir o curso na UFRGS, concluído em 1945.