Saturday, March 04, 2023

3.126 - AMICOR (25)

 3.126 - AMICOR (25) 

#Dra. Valderês Antonietta Robinson Achutti (*13/06/1931+15/06/2021)

Cinderela na Disney
#Slideshow: 96 fotos de abertura Clicar em apresentação de slides

#CREMERS
#Ramalhete de flores...
Texto meu de dez anos atrás ressuscitado pelo computador (Dra. Valderês viveu ainda oito anos)
Lembrei-me do uso frequente da designação simbólica das mulheres como flores, a propósito
do Dia Internacional da Mulher (08 de março de 2013). Também como se costuma
homenageá-las enviando-lhes flores, pensei em preparar um ramalhete embora ficasse
preocupado em deixar alguma de fora. Entretanto como meu jardim é muito grande, eu não
poderia alimentar a pretensão de esgota-las, nem seria conveniente colhe-las todas.
Assim resolvi ir juntando aquelas que me estão mais próximas, ou ao alcance da memória mais
imediata.
Obviamente a primeira que alcancei foi minha mãe, Dona Luiza, mesmo não estando mais por
aqui, senti o seu perfume. Logo em seguida encontrei a Valderês Antonietta, a quem dediquei há sessenta e dois anos passados (1951) uma poesia “velho jardim abandonado”, cuja inspiração gostaria que ainda hoje servisse para tranquilizar seus medos e ansiedades. Logo juntei nossas filhas Ana Lúcia (também médica) e Lucia Helena, e nossa neta Júlia.
Assim como a Valderês gosta e sabe montar belos arranjos de flores, estas já seriam suficientes
para nos deslumbrar, mas não resisti a tentação de colher mais algumas, cada vez mais
correndo o risco de não conseguir dar a atenção merecida, e não fazer a escolha adequada.
Encontrei minhas irmãs, Lia Maria e Maria Helena, extensões de minha mãe; e minha cunhada
Wanyce, extensão de Dona Lea, de quem também desabrochou a Valderês. A Celita Ludvig
presente em nossas vidas há mais de quarenta anos, quase se confundindo com nossas filhas.
Algumas outras, além de embelezar o buque, tem nos ajudado a cuidar da saúde e beleza das
demais: a mastologista Maira Caleffi, a geriatra Laura Barcellos, a psiquiatra Ana Luiza Camozzatto de Pádua, a psicóloga Daniella Turkienicz, a professora de Pilates Rafaela de Macedo e a dentista Flávia Alice Rentsch.
A Romilda Lopes de Almeida toma conta de nossas extensões e arquétipos rurais.
Olhando mais longe: Maria Luiza Link Cechella da qual guardo lembrança de uma mulher forte
e lutadora, provavelmente a pioneira, como parteira, em atividades na área da saúde na família.
A Margareth Catherina Sofia filha do Professor Böbien que encontrou com Jacob Adamy na aventura da imigração, mais de um século antes de minha existência, mas que nos deixou seu perfume.
Dona Claudina Lichtler Robinson, avó da Valderês. Minhas avós Madalena e Amantina. Minha
madrinha Tia Ramza Rechden. Tia Cecília, várias vezes ajudando a cuidar de nossos filhos
quando ainda crianças. Das primas, certamente a mais próxima tem sido a Ilse Pizani.
Há canteiros de flores que enfeitam nossas vidas profissionais onde se destacam Maria Inês
Reinert Azambuja e Marianne Burle de Figueiredo. Mais de uma centena de AMICOR e um
número respeitável e variado de amigas de outras redes sociais (Facebook, Twitter e Linkedin),
bem como correspondentes frequentes como Albertina Helena Pires da Rocha, Clélia Reinert,
Clélia Mandelli. 
Um enorme canteiro com florações de clientes. Nossas duas centenárias atuais Dona Laurita
Pereira Donadio e Dona Maria Ribeiro da Silva Tavares. Nossas nonagenárias: Zuleika Rosa
Guedes, Pasqualina Biamonte Rosito, Maria da Glória Rabelo Schuch, Linda Suamy Ainhorn e
outras mais. Fica complicado siquer citar as de menos idade...
Se tentasse colocar no mesmo ramalhete todas aquelas que já não estão mais por aqui, seria
uma tarefa impossível numa lista a ser construída para acomodar cerca de 55 anos de
atividade profissional.
(pretendo tentar para a próxima semana atualizar um pouco mais o ramalhete...)

#Cesar Victora
Me chamou a atenção o artigo do IHME sobre a imunidade fornecida pela infecção pelas primeiras variantes de COVID contra novas variantes.

Meu filho Gabriel publicou agora em janeiro na Nature a primeira comprovação experimental sobre esse fenômeno de "original antigenic sin", mostrando que a memória imunológica é fortemente influenciada pela primeira variante que um indivíduo enfrenta. Ver abaixo o link: 

#The Rockfeller University
Gabriel Victora

Gabriel D. Victora
Laurie and Peter Grauer Assistant Professor
Laboratory of Lymphocyte Dynamics

Filho do AMICOR Prof. Cesar Gomes Victora

flu vaccine

A legendary virologist coined the term Original Antigenic Sin to reflect his frustration with the body’s bias against the first flu strain it encounters (iStock).

Our immune systems react most strongly to the viral strains we encountered in our childhoods. Scientists call this original antigenic sin (OAS)—the body’s first blush with a virus like influenza or COVID being the “original sin” that forever biases its immune response against newer strains. According to the OAS theory, no matter how many flu vaccines or COVID boosters we receive, our bodies would stubbornly insist on churning out tired antibodies against a bygone strain of a virus.

#National Geographic Magazine

Today's 5-year-olds will likely live to 100. 

For children in wealthier nations, 80 will be the new 60. That means a life filled with day-to-day technological advances—and a new way of thinking about school, work, and retirement.

PUBLISHED FEBRUARY 24, 2023 BY TRISTAN MCCONNEL

Five-year-old Peggy Hawkins wants to be a penguin when she grows up. Even at her young age she concedes it’s unlikely, but being pragmatic she has backups, including dancer. Her playful visions of the future reflect the enthusiasm and unconstrained imagination of this cheerful British girl, and while she won’t become a penguin, something almost as confounding is a near certainty: Peggy Hawkins will live to 100.

According to demographers, today’s five-year-olds have a better chance than ever of living to be centenarians, and by 2050 it’ll likely be the norm for newborns in wealthier nations, such as the United States, Europe, or parts of Asia. That longevity means Peggy, and others of her generation, will live lives that are not just longer, but fundamentally different than the lives of their parents and grandparents.

“What worries us about living long is getting old,” says Andrew Scott, a London School of Business economics professor and co-author of The 100-Year Life. Yet Scott reckons fears of a “Silver Tsunami,” with overburdened young workers toiling to keep their decrepit parents in pensions and adult diapers gets it all wrong. “People are living for longer, on average they’re healthier for longer. It’s amazing how we turn this into bad news.”

A century of medical advances already has extended life expectancy, while improving education, growing prosperity, and greater female choice are reducing fertility rates. The world population reached nine billion in November, but the growth rate is slowing with numbers expected to peak mid-century and then start to reduce. Meanwhile, the proportion of over-65s is already one in 10 and set to reach one in four in the US by 2050. A less populated world, inhabited by older people is on the horizon./.../



#MEDSCAPE

Megan Brooks February 24, 2023

Regular use of over-the-counter laxatives has been tied to a significantly increased risk of dementia, particularly among those who use multiple types of laxatives or osmotic laxatives.

Among more than 500,000 middle-aged or older adults in the UK Biobank, those who reported regular laxative use had a 51% increased risk of dementia due to any cause, compared to their counterparts who did not regularly use laxatives.

Individuals who only used osmotic laxatives had a 64% increased risk compared to peers who did not use laxatives, while those using one or more types of laxatives, including bulk-forming, stool-softening, or stimulating laxatives, had a 90% increased risk./.../

#O Brasil e o Mundo que Queremos

Entrevista  para o prof. Isaac Roitman, da Universidade de Brasília

#HMV

#ASRM

#NGM - maps

1925 THE ARCTIC

This November 1925 supplement map accompanied two reports from the MacMillan expedition to the Arctic, including an account by the famous aviator and explorer Richard E. Byrd, one of the first pilots to explore the Arctic from the air. The large white area left of center...
COURTESY NATIONAL GEOGRAPHIC MAPS 


#Nat. Cardiovac. Res.

Recomendado pela AMICOR Maria Inês Reinert Azambuja que tem parte importante
no desenvolvimento mundial dessa linha de pesquisa científica.

Autoimmune features of atherosclerosis

Yevgeniya Nusinovich
Atherosclerosis, the formation of plaque in the arteries, is a key pathology contributing
to myocardial infarction, stroke, and other disorders causing large numbers of deaths
in humans. Atherosclerosis had been traditionally viewed as a lipid disorder, and
inflammation is known to play a major role as well, but now Depuydt et al. have
identified a potential autoimmune aspect to it. Through detailed analysis of T cells
and their interactions with macrophages in the atherosclerotic plaques and blood of
human patients, the authors identified T cells with an autoimmune phenotype, which
may indicate additional directions for future treatment approaches.
Nat. Cardiovasc. Res. 10.1038/s44161-022-00208-4 (2023).
#
My Bookmarks

NEUROSCIENCE | ALL TOPICS

 

How Loneliness Reshapes the Brain

By MARTA ZARASKA

Feelings of loneliness prompt changes in the brain that further isolate people from the social contact they crave.

Read the article

MACHINE LEARNING

 

In Neural Networks, Unbreakable Locks Can Hide Invisible Doors

By BEN BRUBAKER

Cryptographers have shown how perfect security can undermine machine learning models.

Read the article


Related: 
Researchers Identify ‘Master Problem’
Underlying All Cryptography

By Erica Klarreich (2022)

PUZZLES

 

How Many Exoplanets Can You Visit in Quanta’s New Math Game?

By THOMAS LIN

Explore a universe of numbers and arithmetic in our new interactive math game, Hyperjumps!

About Hyperjumps! | Play the game


Related: 
The Map of Mathematics

Text by Kevin Hartnett
Design by Kim Albrecht and Jonas Parnow (2020)

Q&A

 

An Applied Mathematician With an Unexpected Toolbox

By RACHEL CROWELL

Lek-Heng Lim uses tools from algebra, geometry and topology to answer questions in machine learning.

Read the interview


Related: 
A New Approach to Understanding
How Machines Think

By John Pavlus (2019)

QUANTA SCIENCE PODCAST

 

Brightest-Ever Space Explosion Reveals Possible Hints of Dark Matter

Podcast hosted by SUSAN VALOT;
Story by JONATHAN O'CALLAGHAN

In 2022, astronomers saw the brightest gamma-ray burst ever observed by humans. Did it also offer a glimpse of dark matter?

Listen to the podcast

Read the article

Around the Web

Reconstructed Prebiotics
For decades, origin-of-life researchers have debated how amino acids were first linked together to form proteins in the absence of ribosomes, the cell organelles that do the job today. Recent work suggests that a “protoribosome” made from a bundle of RNA could have done the trick, Amber Dance reports for Nature. In a story for Quanta published last May, Yasemin Saplakoglu reported on an alternative hypothesis that the earliest peptides could have grown at the ends of paired strands of RNA. Further experiments aim to unveil the true origin of life’s machinery.


Brain Momifications
“Mommy brain” is a real thing in new mothers, but not as it’s disparagingly portrayed in popular culture. A mother’s brain reorganizes its connections to prepare for learning how to keep a baby alive, explains Aimee Cunningham for Science News. Understanding the circuitry that gets turned on in parents’ brains is vital to understanding disorders such as postpartum depression. In 2020, the molecular neuroscientist Catherine Dulac spoke with Claudia Dreifus for Quanta about her research into sex-specific behaviors and postpartum depression in mothers.
Click to view imagesPaul Berg, the Nobel Prize-winning biochemist whose ground-breaking experiments in gene-splicing reshaped cancer research and helped spawn the multibillion-dollar biotechnology industry, has died at his home on the Stanford University campus. He was 96.
READ MORE
#TIME
9 Photos That Capture a Year of Pain—and Resilience—in Ukraine
BY SANYA MANSOOR AND TIME PHOTO DEPARTMENT
TIME speaks to photojournalists on their work the past year—and the moments that have stayed with them.
READ MORE »

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