Alzheimer and Infections

June 8, 2020

Can Infections Cause Alzheimer Disease?

Anthony L. Komaroff, MD¹

Author Affiliations Article Information

JAMA. 2020;324(3):239-240. doi:10.1001/jama.2020.4085

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Can Infections Cause Alzheimer Disease?

Anew model of the pathogenesis of Alzheimer disease (AD) is challenging the old. New disease models do not always replace old models. Instead, the new sometimes completes the old.

The Old Model

Amyloid-β, Tau, and APOE

The pathogenesis of Alzheimer disease (AD) remained a mystery for 80 years. However, in recent decades, 3 molecules have been found to play crucial roles: amyloid-β (Aβ), found in plaques; tau, found in neurofibrillary tangles; and apolipoprotein E (APOE).¹ Individuals who carry 2 copies of the allele for APOE*E4 are about 10 times more likely to develop the disease than those who have no copies of this allele./.../

Malária

Microbe blocks malaria in mosquitoes A microbe discovered in mosquitoes on the shores of Lake Victoria in Kenya seems to prevent the insect from harbouring the malaria parasite. The microsporidian symbiont, Microsporidia MB, occurs naturally in the insect and doesn’t seem to harm them. It’s not exactly clear how the microbe prevents malaria in the mozzies. Researchers hope that infecting more mosquitoes with Microsporidia MB could someday limit malaria transmission to humans. BBC | 4 min readReference: Nature paper

Pandemics

How pandemics shaped society

In his new book, historian Frank Snowden argues that infectious diseases have shaped social evolution no less powerfully than have wars, revolutions and economic crises. Reviewer Laura Spinney notes that we still seem to be repeating many of the mistakes that triggered or exacerbated epidemics in the past.

Nature | 5 min read

Doenças transmissíveis: Antropologia

Da AMICOR Cristianne Famer Rocha
para Amigos, Grupo-de-orientacao-ampliado, GT, Saude, mspbrasil, PET, divulga-saude-coletiva, 2016, GEASDEM, HIFA-pt

Antropologia das doenças transmissíveis: interpretações do contágio e diferenças culturais. 1. ed. Fortaleza: EdUECE, 2018. v. 1. 220p .Andrea Caprara

Este livro apresenta os resultados de diversas pesquisas realizadas pelo autor sobre o tema do contágio ao longo das últimas duas décadas, em diversos países. Trata-se de material inédito na língua portuguesa e reorganizado no intuito de identificar um único fio condutor e elementos comuns entre material recolhido em contextos socioculturais bem diversificados, bem diferenciados.

Os diversos capítulos expõem, a seu modo, conclusões parcialmente publicadas em periódicos e capítulos de livros. Ebook disponível em:  http://www.uece.br/eduece/dmdocuments/Antropologia_das_doencas_transmissiveis_EDUECE.pdf?fbclid=IwAR3R0QmqiKLc3EuUoshvB2RblwJZAec1Jg9xVtSbEzWWQVOr-Ieh7xQazN8