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Sunday, June 19, 2022

3.090 - AMICOR (25)

  3.090 - AMICOR (25) 

Caríssimos AMICOR, como sabem já fazem 25 anos que estou na rede, já andei fazendo várias mudanças e adaptações, mas cada vez mais me questiono se devo manter esta atividade e, no caso, o que e como me atualizar. Também foi minha proposta desde o início ter um instrumento para guardar o que me interessa, disponibilizando-o para meus amigos, ou a quem mais possa interessar...

Para encontrar com mais tranquilidade meu caminho daqui por diante, seria de muita valia se pudesse contar com a opinião, crítica e sugestões de quem tem me visitado, ainda mais porque não conto mais com o conselho de quem me ajudou durante setenta anos.

Muito obrigado, Aloyzio.

#Dra. Valderês Antonietta Robinson Achutti (*13/06/1931+15/06/2021

Aproveitando a celebração do dia do Pai (19/06): Não lembro onde nem quando , mas tenho saudade do calorzinho dela...
                                        (clicar  em Apresentação de Slides)


Recomendado pela AMICOR Maria Inês Reinert Azambuja


Ryan Syrek


17 de junho de 2022 

Um dos medicamentos geralmente mais prescritos no mundo, a metformina, é usado primariamente para tratar o diabetes mellitus tipo 2. Novas pesquisas sobre seus potenciais efeitos benéficos para tratar outras doenças, bem como questões emergentes sobre seus efeitos adversos, fizeram com que este medicamento se tornasse o tema clínico mais buscado da semana. Talvez mais especificamente, os resultados recém-divulgados de um ensaio clínico marcante tenham sido muito decepcionantes/.../
#Nature briefing

My Bookmarks



By Exploring Virtual Worlds, AI Learns in New Ways


Intelligent beings learn by interacting with the world. Artificial intelligence researchers have adopted a similar strategy to teach their virtual agents new skills.

Read the article



The Spooky Quantum Phenomenon You’ve Never Heard Of


Contextuality isn’t as famous as nonlocality, but researchers think it may be what gives quantum computers an advantage over their classical cousins.

Read the blog

How Bell’s Theorem Proved
‘Spooky Action at a Distance’ Is Real

by Ben Brubaker (2021)



An Immunologist Fights Covid with Tweets and a Nasal Spray


On Twitter, immunologists like Akiko Iwasaki are educating the public in real time about developments in the pandemic, including the potential of nasal spray vaccines.

Read the interview

‘Trained Immunity’ Offers Hope
in Fight Against Coronavirus

by Esther Landhuis (2020)



Mathematical Connect-the-Dots Reveals How Structure Emerges


A new proof identifies precisely how large a mathematical graph must be before it contains a regular substructure.

Read the blog

Surfaces Beyond Imagination Are
Discovered After Decades-Long Search

by Leila Sloman



This Animal’s Behavior Is Mechanically Programmed

Podcast hosted by SUSAN VALOT;

Biomechanical interactions, rather than neurons, control the movements of one of the simplest animals. The discovery offers a glimpse into how animal behavior worked before neurons evolved.

Listen to the podcast

Read the article

Around the Web

When Viruses Get Worse
Viruses often get milder over time, but that’s far from always the case. For The New York Times, Carl Zimmer considers the deadliest vertebrate virus, myxoma, which in the 1990s evolved to become more virulent among the rabbit populations it ravaged. The uncertainty of virus evolution is relevant to the COVID-19 pandemic. Virologists are trying to better understand this by mapping out the “fitness landscape” of all possible mutations of SARS-CoV-2, Carrie Arnold reported for Quanta in January.

Physicists Spot Strong Signs
Physicists think they have seen the first convincing evidence for the “tetraneutron,” a short-lived particle composed of four neutrons, Emily Conover reports for Science News. Studying this exotic particle could help us learn more about nuclear forces. The strong force binds neutrons together but also keeps individual neutrons together — until the weak force eventually wins and the neutron decays. In 2018 Natalie Wolchover wrote for Quanta about what we can learn from studying neutron lifetimes.
Follow Quanta

#The Marginalian - Maria Popova

The dandelion and the meaning of life, 20 reasons for being, poet Elizabeth Alexander on how literature widens the portal of the possible

The Dandelion and the Meaning of Life: G.K. Chesterton on How to Dig for the “Submerged Sunrise of Wonder”

There is a myth we live with, the myth of finding the meaning of life — as if meaning were an undiscovered law of physics. But unlike the laws of physics — which predate us and will postdate us and made us — meaning only exists in this brief interlude of consciousness between chaos and chaos, the interlude we call life. When you die — when these organized atoms that shimmer with fascination and feeling — disband into disorder to become unfeeling stardust once more, everything that filled your particular mind and its rosary of days with meaning will be gone too. From its particular vantage point, there will be no more meaning, for the point itself will have dissolved — there will only be other humans left, making meaning of their own lives, including any meaning they might make of the residue of yours./.../



Mental health is critically important to everyone, everywhere. All over the world, mental health needs are high but responses are insufficient and inadequate. This “World Mental Health Report” is designed to inspire and inform better mental health for all. It highlights why and where change is needed and how it can be achieved.


#AEON Magazine

In the jungle of Suriname, Maria Sibylla Merian discovered insect metamorphosis

Borrowing from the elegant visual style of the German-born Swiss naturalist, entomologist and botanical artist Maria Sibylla Merian (1647-1717), this animation celebrates her many notable contributions to the natural sciences in an age when such work was widely considered the domain of men. A dedicated observer of plants and insects in particular, two of her many achievements include helping to dispel the once widely held belief that insects spontaneously emerge from dust, mud or rotten meat, and observing metamorphosis in rich detail. And 300 years after her death, her seminal book, The Metamorphosis of the Insects of Suriname (1705), which depicts insects and plants in the jungles of South America, is still considered one of the most beautiful and groundbreaking entomology books ever assembled, with editions of the pioneering work being reprinted as recently as 2010. Video by The Royal Society and BBC Ideas Animation: Studio Panda 30 May 2022


US Preventive Services Task Force 
Evidence Report
June 21, 2022

Vitamin and Mineral Supplements for the Primary Prevention of Cardiovascular Disease and CancerUpdated Evidence Report and Systematic Review for the US Preventive Services Task Force

JAMA. 2022;327(23):2334-2347. doi:10.1001/jama.2021.15650
Conclusions and Relevance  Vitamin and mineral supplementation was associated with little or no benefit in preventing cancer, cardiovascular disease, and death, with the exception of a small benefit for cancer incidence with multivitamin use. Beta carotene was associated with an increased risk of lung cancer and other harmful outcomes in persons at high risk of lung cancer././
June 21, 2022

New Test to Help Diagnose Alzheimer Disease

JAMA. 2022;327(23):2281. doi:10.1001/jama.2022.9847

The FDA recently permitted Fujirebio Diagnostics to market the first in vitro diagnostic biomarker test for early detection of amyloid plaques associated with Alzheimer disease.

The Lumipulse G β-Amyloid Ratio (1-42/1-40) test could potentially eliminate the need for positron emission tomography (PET) scans to assess amyloid plaques in patients’ brains, Jeff Shuren, MD, JD, director of the FDA’s Center for Devices and Radiological Health, said in a statement.

To expedite development and review, the agency had designated the Lumipulse test as a breakthrough device, a classification reserved for devices that might more effectively treat or diagnose life-threatening or irreversibly debilitating diseases or conditions.

The new test is intended for use among patients aged 55 years or older to help determine whether their cognitive impairment is due to Alzheimer disease. It is designed to measure the ratio of β-amyloid 1-42 and β-amyloid 1-40 concentrations in cerebrospinal fluid (CSF), which can help determine the likelihood of amyloid plaques in the brain.

The Lumipulse test isn’t intended to be used as a screening or stand-alone diagnostic assay because patients with other neurological conditions, as well as older cognitively healthy people, could receive a positive result. The assay should be used only in conjunction with other clinical evaluations, according to the FDA.

The agency evaluated the test’s safety and effectiveness based on the results of a clinical study that compared results from 292 CSF samples with PET scan findings. Of the samples that had positive results on the Lumipulse test, 97% came from patients whose PET scans revealed the presence of amyloid plaques. Of the samples that had negative results on the Lumipulse test, 84% also had a negative amyloid PET scan.


Global Dementia Care Spending and Future Spending Scenarios 2000-2050

This dataset contains retrospective estimates for healthcare spending attributable to dementia for 195 countries from 2000 to 2019 and prospective spending estimates from 2020 to 2050 under multiple scenarios. Intermediate and final estimates are provided. Intermediate estimates include community based care rate (CBC), nursing home based care rate (NHBC), community based care unit cost, and nursing home based care unit cost. Final estimates are attributable dementia spending. All spending is reported in 2019 United States dollars. Future estimates report the same model outputs as those reported in the retrospective model but include both reference and alternative scenarios based on accelerated care setting rates and units costs.
Publication year 
Suggested citation 
Institute for Health Metrics and Evaluation (IHME). Global Dementia Care Spending and Future Spending Scenarios 2000-2050. Seattle, United States of America: Institute for Health Metrics and Evaluation (IHME), 2022.
Terms and conditions

Data made available for download on IHME Websites can be used, shared, modified or built upon by non-commercial users in accordance with the IHME FREE-OF-CHARGE NON-COMMERCIAL USER AGREEMENT. For more information (and inquiries about commercial use), visit IHME Terms and Conditions.

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#Research Gate                                                                          

Rethinking the vaccine landscape

In this whitepaper, learn from Dr. Sanjay Garg, Senior Expert Scientist, Sanofi Pasteur about the direction of vaccine development, potential hurdles researchers and manufacturers might face, and how lessons learnt from COVID-19 will shape the future of vaccine development.
Rethinking the vaccine landscape