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Michael Stumvoll, Barry J Goldstein, Timon W van Haeften
(Referred by Maria Inês Reinert Azambuja)
Type 2 diabetes mellitus has become an epidemic, and virtually no physician is without patients who have the disease. Whereas insulin insensitivity is an early phenomenon partly related to obesity, pancreas beta-cell function declines gradually over time already before the onset of clinical hyperglycaemia. Several mechanisms have been proposed, including increased non-esterified fatty acids, inflammatory cytokines, adipokines, and mitochondrial dysfunction for insulin resistance, and glucotoxicity, lipotoxicity, and amyloid formation for beta-cell dysfunction.
Moreover, the disease has a strong genetic component, but only a handful of genes have been identified so far: genes for calpain 10, potassium inward-rectifier 6.2, peroxisome proliferator-activated receptor gama insulin receptor substrate-1, and others. Management includes not only diet and exercise, but also combinations of antihyperglycaemic drug treatment with lipid-lowering, antihypertensive, and anti platelet therapy.
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