Drug lowers inflammatory markers associated with risk for heart attack

Drug lowers inflammatory markers associated with risk for heart attack: "
'The clinical trial by Hakonarson et al provides an exciting attempt to translate genetic findings to clinical applications. How close clinicians and researchers are to the promised destination of a genome-based diagnostics and therapeutics for MI and stroke remains uncertain. This phase 2 pharmacogenetic trial and its implications must be interpreted with the same degree of caution as with any newly proposed risk factor. Continued research is warranted to replicate the original ALOX5AP association. Careful attention to proper study design will be essential to make future trials credible. … As with nongenetic risk factors, the emerging evidence will need to be carefully and continuously examined to ensure that the benefits outweigh the risks as genomics-based strategies are tested in clinical trials,' concludes Dr. O'Donnell. "