Fixed-dose unfractionated heparin, given subcutaneously, as effective as low-molecular-weight heparin for VTE

Fixed-dose unfractionated heparin, given subcutaneously, as effective as low-molecular-weight heparin for VTE:
"August 22, 2006 Michael O'Riordan
Hamilton, ON - Fixed-dose subcutaneous unfractionated heparin, without monitoring of activated partial thromboplastin time (APTT), is as effective as fixed-dose low-molecular-weight heparin in patients with acute venous thromboembolism, according to the results of a new study [1]. In addition, the administration of unfractionated heparin was safe, with no increased bleeding risks, and could be considered an alternative for outpatient use, say investigators.

'We're pleased with the results, and we feel the findings are consistent with our expectations, that there would not be a difference between outcomes when you use unfractionated heparin and low-molecular-weight heparin in the same way,' lead investigator Dr Clive Kearon (McMaster University, Hamilton, ON) told heartwire. 'I think the data will be of interest to the medical community because it departs from what has been usual practice with a drug that has been in use clinically now for over 50 years.'

The results of the study are published in the August 23, 2006 issue of the Journal of the American Medical Association."