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Friday, May 08, 2009

Obesity, inflammation, and atherosclerosis

Nature Reviews Cardiology, advance online publication, Published online 28 April 2009 |doi:10.1038/nrcardio.2009.55

Subject Category: Vascular disease

Obesity, inflammation, and atherosclerosis

Viviane Z. Rocha1 & Peter Libby1  About the authors

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Understanding of the pathophysiology of atherogenesis has evolved substantially during the last few decades. Atherosclerosis was once identified as a lipid-storage disease, but is now recognized as a subacute inflammatory condition of the vessel wall, characterized by infiltration of macrophages and T cells, which interact with one another and with cells of the arterial wall. The pathological mechanisms of obesity recapitulate many features of the inflammatory processes at work in atherosclerosis. Our current appreciation of the similarities between obesity and atherosclerosis has already fostered innovations for the diagnosis, prognosis, and prevention of these two conditions./.../

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