Exposure to Airborne Fine Particulate Matter and Cigarette Smoke

Cardiovascular Mortality and Exposure to Airborne Fine Particulate Matter and Cigarette Smoke. Shape of the Exposure-Response Relationship

C. Arden Pope III PhD^*, Richard T. Burnett PhD, Daniel Krewski PhD, Michael Jerrett PhD, Yuanli Shi MD, Eugenia E. Calle PhD, and Michael J. Thun MD

From Brigham Young University, Provo, Utah (C.A.P.); Health Canada, Ottawa, Ontario, Canada (R.T.B.); University of Ottawa, Ottawa, Ontario, Canada (D.K., Y.S.); University of California, Berkeley (M.J.); and American Cancer Society, Atlanta, Ga (E.E.C., M.J.T.).

^* To whom correspondence should be addressed. E-mail: cap3@byu.edu.

Background—Fine particulate matter exposure from both ambient air pollution and secondhand cigarette smoke has beenassociated with larger risks of cardiovascular mortality than would be expected on the basis of linear extrapolations of therelative risks from active smoking. This study directly assessed the shape of the exposure-response relationship between cardiovascular mortality and fine particulates from cigarette smoke and ambient air pollution.

Methods and Results—Prospective cohort data for >1 million adults were collected by the American Cancer Society as part of the Cancer Prevention Study II in1982. Cox proportional hazards regression models that included variables for increments of cigarette smoking and variables to control for education, marital status, body mass, alcohol consumption, occupational exposures, and diet were used to describe the mortality experience of the cohort. Adjusted relative risks of mortality were plotted against estimated average daily dose of fine particulate matter from cigarette smoke along with comparison estimates for secondhand cigarette smoke and air pollution. There were substantially increased cardiovascular mortality risks at very low levels of active cigarette smoking and smaller but significant excess risks even at the much lower exposure levels associated with secondhand cigarette smoke and ambient air pollution.

Conclusions—Relatively low levels of fine particulate exposure from either air pollution or secondhand cigarette smoke are sufficient to induce adverse biologicalresponses increasing the risk of cardiovascular disease mortality. The exposure-response relationship between cardiovascular disease mortality and fine particulate matter is relatively steep at low levels of exposure and flattens out at higher exposures.