Hidden molecular structures in proteins revealed
Improved X-ray diffraction software uses statistical methods
December 23, 2014
A membrane protein called cysZ, imaged in three dimensions with Phenix software, using data that could not previously be analyzed (credit: Los Alamos National Laboratory)
Los Alamos National Lab scientists have developed statistical methods that allow for creating three-dimensional pictures of previously hidden molecular structures in proteins.
To view the proteins, researchers produce billions of copies, dissolve them in water, and grow crystals of the protein, then shine a beam of X-rays and measure the brightness of each of the thousands of diffracted X-ray spots that are produced./.../
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