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Remo Rohs is looking for some deep connections: He’s integrating genomics and structural biology to uncover some significant insights into how proteins recognize DNA.
While genomics deciphers DNA by studying the sequences of base pairs that encode genetic information, structural biology explores the impact of the actual 3-D structure of DNA. Rohs, however, aims to unite the two fields into something new — and hopefully more useful.
“Structural biology and genomics are big fields, but there is little interaction between these two worlds,” said Rohs, assistant professor of biological sciences, chemistry and physics at the USC Dornsife College of Letters, Arts and Sciences. “Genomics thinks of entire genomes in terms of sequence, and structural biology thinks of 3-D structures at high resolution but limited size.”/.../