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Wednesday, August 09, 2017

HDAC2, Sp3, DNA, Clotho, Doença de Alzheimer

Blocking Key Enzyme May Reverse Memory Loss in Alzheimer’s

Image shows an old person and photos.MIT researchers have demonstrated a new way to reverse memory loss by blocking an enzyme known as HDAC2. image is credited to Jose-Luis Olivares/MIT.
by Neuroscience News
Researchers discover targeting the HDAC2 enzyme, by blocking its interaction with Sp3, resulted in the reversal of memory loss in mice. The findings, published in Cell Reports, may offer a new avenue for treating memory loss in Alzheimer's disease.
Neuroscience News | August 9, 2017 at 10:50 am | Tags: Sp3 | URL:
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Possible Anti-Aging Brain Therapy Shows Promise in Mice
Old animals injected with the hormone component klotho learn and remember betterBy Simon Makin on August 8, 2017

Clotho, one of the Three Fates of Greek mythology, carried the weighty responsibility of spinning the thread of human life. It seems fitting then that a protein linked to reducing and extending life spans should take its name from this mythic figure. Researchers discovered the klotho protein in 1997, when they found that diminished levels seemed to make the animals age faster. Conversely, mice genetically engineered to maintain elevated klotho levels live 30 percent longer than normal mice. Recent research hints that the protein itself could form the basis of anti-aging therapies./.../

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