A study in mice has hinted at the impact that early life trauma and stress can have on genes, and how they can result in behavioural problems.
Scientists described the long-term effects of stress on baby mice in the journal Nature Neuroscience.
Stressed mice produced hormones that "changed" their genes, affecting their behaviour throughout their lives.
This work could provide clues to how stress and trauma in early life can lead to later problems.
Mice that are abandoned as pups have behavioural problems later on life
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Showing posts with label Perinatal risk. Show all posts
Showing posts with label Perinatal risk. Show all posts
Thursday, December 17, 2009
Early life stress 'changes' genes
Friday, October 02, 2009
Nutrition in early life: a global priority
Artigo de nosso AMICOR Cesar Gomes Victora no The Lancet
Nutrition in early life: a global priority
On Oct 14—18, Berlin will host the first World Health Summit. The prevention of adult chronic diseases through interventions in young children is one of the summit's key topics. Promotion of good nutrition in early life is essential for health later in life because either undernutrition or overnutrition can cause lifelong, irreversible damage. This matter is especially relevant at a time when the global food and financial crises are disproportionately affecting nutrition of the poorest families in low-income and middle-income countries./.../
Friday, January 04, 2008
Perinatal Risk Factors for Ischemic Heart Disease. Disentangling the Roles of Birth Weight and Preterm Birth
Perinatal Risk Factors for Ischemic Heart Disease. Disentangling the Roles of Birth Weight and Preterm Birth Magnus Kaijser MD, PhD*, Anna-Karin Edstedt Bonamy MD, Olof Akre MD, PhD, Sven Cnattingius MD, PhD, Fredrik Granath PhD, Mikael Norman MD, PhD, and Anders Ekbom MD, PhD
From the Clinical Epidemiology Unit, Department of Medicine (M.K., O.A., F.G., A.E.), Department of Woman and Child Health (A.-K.E.B.), Department of Medical Epidemiology and Biostatistics (S.C.), and Department of Clinical Science, Intervention, and Technology (M.N.), and Department of Clinical Sciences at Danderyds Hospital (M.K.), Karolinska Institutet, Stockholm, Sweden.
* To whom correspondence should be addressed. E-mail: magnus.kaijser@ki.se
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Background—Several studies have reported an association between low birth weight and ischemic heart disease, but it remains unclear whether the association is mediated through poor fetal growth or short gestational duration.
Methods and Results—In a cohort study, we have identified all subjects born preterm or with a low birth weight at 4 major delivery units in Sweden from 1925 through 1949. For comparison, an equal number of subjects with none of these criteria were identified within the same source population. The study population consists of 6425 subjects, of whom 2931 were born before 37 weeks of gestation and 2176 had a birth weight <2500 g. Fetal growth was estimated through birth weight for gestational age. The cohort was followed up for occurrence of ischemic heart disease through the nationwide Hospital Discharge and Cause of Death Registries during the period of 1987 through 2002. In the cohort, 617 cases of ischemic heart disease occurred. Compared with subjects with a normal fetal growth, those born small for gestational age (birth weight -2 SD below the mean) were at increased risk of ischemic heart disease (adjusted hazard ratio, 1.64; 95% confidence interval, 1.23 to 2.18). The negative association between fetal growth and risk of ischemic heart disease was independent of gestational duration.
Conclusions—The association between low birth weight and adult risk of ischemic heart disease appears to be mediated entirely by poor fetal growth.
From the Clinical Epidemiology Unit, Department of Medicine (M.K., O.A., F.G., A.E.), Department of Woman and Child Health (A.-K.E.B.), Department of Medical Epidemiology and Biostatistics (S.C.), and Department of Clinical Science, Intervention, and Technology (M.N.), and Department of Clinical Sciences at Danderyds Hospital (M.K.), Karolinska Institutet, Stockholm, Sweden.
* To whom correspondence should be addressed. E-mail: magnus.kaijser@ki.se
'//-->
.
Background—Several studies have reported an association between low birth weight and ischemic heart disease, but it remains unclear whether the association is mediated through poor fetal growth or short gestational duration.
Methods and Results—In a cohort study, we have identified all subjects born preterm or with a low birth weight at 4 major delivery units in Sweden from 1925 through 1949. For comparison, an equal number of subjects with none of these criteria were identified within the same source population. The study population consists of 6425 subjects, of whom 2931 were born before 37 weeks of gestation and 2176 had a birth weight <2500 g. Fetal growth was estimated through birth weight for gestational age. The cohort was followed up for occurrence of ischemic heart disease through the nationwide Hospital Discharge and Cause of Death Registries during the period of 1987 through 2002. In the cohort, 617 cases of ischemic heart disease occurred. Compared with subjects with a normal fetal growth, those born small for gestational age (birth weight -2 SD below the mean) were at increased risk of ischemic heart disease (adjusted hazard ratio, 1.64; 95% confidence interval, 1.23 to 2.18). The negative association between fetal growth and risk of ischemic heart disease was independent of gestational duration.
Conclusions—The association between low birth weight and adult risk of ischemic heart disease appears to be mediated entirely by poor fetal growth.
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