Prostate Cancer Therapy Linked to Diabetes and Heart Disease - CME Teaching Brief® - MedPage Today: "BOSTON, Sept. 19 -- Androgen deprivation with a GnRH agonist for local or regional prostate cancer is associated with an increased risk of diabetes, coronary heart disease, heart attack, and sudden cardiac death, according to researchers here.
An observational analysis of more than 73,000 men with local or regional disease showed that treatment with a gonadotropin-releasing hormone (GnRH) agonist increases the risk of diabetes by 44%, with smaller increases in the risks of cardiovascular disease, according to Nancy Keating, M.D., of Harvard Medical School and Brigham and Women's Hospital.
As they make treatment decisions about locoregional disease, 'patients and physicians need to be aware of the elevated risk' of a GnRH agonist, Dr. Keating said. "
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